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PMID: 3415693 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids.

Biochemical and biophysical research communications ·Vol. 155 ·No. 1 ·1988-08-30 ·Pages 38-44

Cashman JR, Lambert C, Sigal E

Abstract

The inhibition of human leukocyte 5-lipoxygenase by 15-hydroperoxyeicosatetraenoic acid and its chemical or enzymatic rearrangement products was investigated. 15-Hydroperoxyeicosatetraenoic acid was the most potent inhibitor tested. The inhibition was found to be time dependent and is not due to chemical or enzymatic decomposition products nor metabolism of 15-hydroperoxyeicosatetraenoic acid to 5,15-dihydroperoxyeicosatetraenoic acid.

MeSH Terms
Arachidonate Lipoxygenases/antagonists & inhibitors Arachidonic Acids/pharmacology Dose-Response Relationship, Drug Eosinophils/drug effects,enzymology,metabolism Humans Hydroxyeicosatetraenoic Acids/metabolism Kinetics Leukotrienes Lipid Peroxides/pharmacology Lipoxygenase Inhibitors
Chemicals
Arachidonic Acids Hydroxyeicosatetraenoic Acids Leukotrienes Lipid Peroxides Lipoxygenase Inhibitors 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid 15-hydroxy-5,8,11,13-eicosatetraenoic acid Arachidonate Lipoxygenases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cashman J R
Department of Pharmaceutical Chemistry and Liver Center, University of California, San Francisco 94115.
Lambert C
Sigal E
Article Info
Journal
Biochemical and biophysical research communications
Abbr.
Biochem Biophys Res Commun
ISSN
0006-291X
DOI
10.1016/s0006-291x(88)81046-5
Published
1988-08-30
Pages
38-44
Language
English
Region
United States
NLM ID
0372516
Subset
IM
Grants
NHLBI NIH HHS · HL-24136 · United States
External Links
PubMed source DOI: 10.1016/s0006-291x(88)81046-5 View journal details
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