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PMID: 339932 Published · ppublish English Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial

Comparison of atenolol and oxprenolol in patients with angina or hypertension and co-existent chronic airways obstruction.

British journal of clinical pharmacology ·Vol. 5 ·No. 2 ·1978-02-00 ·Pages 101-6

Perks WH, Chatterjee SS, Croxson RS, Cruickshank JM

Abstract

1 The effects of atenolol (50 mg and 100 mg) and oxprenolol (80 mg) on respiratory function were studied in ten patients with angina pectoris or hypertension complicated by chronic airways obstruction. 2 In patients with "fixed" airways obstruction, neither atenolol nor exprenolol significantly affected airways resistance. 3 In patients with "labile" airways obstruction, atenolol did not produce a significant increase in airways obstruction, whereas oxprenolol did. 4 Following isoprenaline challenge (1500 microgram by inhalation), atenolol permitted full bronchodilatation, whereas oxprenolol almost completely blocked the action of isoprenaline. 5 Partial agonist activity appears to be of less clinical importance than cardioselectivity.

MeSH Terms

Adult Airway Obstruction/complications,physiopathology Angina Pectoris/complications,physiopathology Atenolol/pharmacology Chronic Disease Clinical Trials as Topic Double-Blind Method Female Heart Rate/drug effects Humans Hypertension/complications,physiopathology Male Middle Aged Oxprenolol/pharmacology Propanolamines/pharmacology Respiration/drug effects Respiratory Function Tests

Chemicals

Propanolamines Atenolol Oxprenolol

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Perks W H

Chatterjee S S

Croxson R S

Cruickshank J M

References (11)

11 references, click to expand

Practolol treatment in asthmatics.
Lancet. 1971 Dec 4;2(7736):1264-5 PMID: 4143623
Human pharmacokinetic and pharmacodynamic studies on the atenolo (ICI 66,082), a new cardioselective beta-adrenoceptor blocking drug.
Br J Clin Pharmacol. 1976 Apr;3(2):267-72 PMID: 973955
Effects of intravenous propranolol and metoprolol and their interaction with isoprenaline on pulmonary function, heart rate and blood pressure in asthmatics.
Eur J Clin Pharmacol. 1975 Apr 4;8(3-4):175-80 PMID: 1233216
Effect of a new beta-adrenergic blocking agent, ICI 66o82, on exercise haemodynamics and airway resistance in angina pectoris.
Br Heart J. 1974 Dec;36(12):1194-1200 PMID: 4155316
Beta-adrenergic blocking drugs.
Br Med J. 1971 Jun 12;2(5762):652 PMID: 4397173
The beta-blocking effect of practolol in asthmatics.
Lancet. 1970 Sep 26;2(7674):662 PMID: 4195795
Cardiac and pulmonary effects of acebutolol.
Lancet. 1975 Jul 19;2(7925):89-93 PMID: 49736
Practolol in the treatment of tachyarrhythmias in patients with bronchial asthma.
Am Heart J. 1972 Nov;84(5):710-2 PMID: 4404793
Metabolic studies on oxprenolol in animals and man by means of radio-tracer techniques and GLC-analysis.
Postgrad Med J. 1970 Nov;:Suppl:32-9 PMID: 4395455
Comparison of the effect of alprenolol and propranolol on specific airway conductance in asthmatic subjects.
Br Med J. 1970 May 30;2(5708):515-6 PMID: 4393346
Effect of propranolol on respiratory function and exercise tolerance in patients with chronic obstructive lung disease.
Chest. 1975 Mar;67(3):287-92 PMID: 1112122

Article Info

Journal

British journal of clinical pharmacology

Abbr.

Br J Clin Pharmacol

ISSN

0306-5251

DOI

10.1111/j.1365-2125.1978.tb01608.x

Published

1978-02-00

Pages

101-6

Language

English

Region

England

NLM ID

7503323

PMCID

PMC1429247

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2125.1978.tb01608.x PMC Full Text View journal details

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Comparison of atenolol and oxprenolol in patients with angina or hypertension and co-existent chronic airways obstruction.

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