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PMID: 3390517 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Nonlinear optical properties of potential sensitive styryl dyes.

Biophysical journal ·Vol. 53 ·No. 5 ·1988-05-00 ·Pages 665-70

Huang JY, Lewis A, Loew L

Abstract

The nonlinear optical properties of dyes that alter their optical characteristics rapidly with membrane potential are described. The second harmonic signals from these dyes characterized in this paper are among the largest that have been detected to date. Structural conclusions are drawn from the second harmonic signals generated by the Langmuir Blodgett monolayers used in these measurements. Our results indicate that with appropriate instrumentation second harmonic signals could readily be detected from living cells stained with these dyes.

MeSH Terms
Cell Membrane/physiology Coloring Agents Lasers Membrane Potentials Models, Biological Spectrophotometry Styrenes Surface Properties
Chemicals
Coloring Agents Styrenes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Huang J Y
Department of Applied Physics, Cornell University, Ithaca, New York 14853.
Lewis A
Loew L
References (5)
5 references, click to expand
  1. Orientation of surfactant molecules at a liquid-air interface measured by optical second-harmonic generation.
    Phys Rev A Gen Phys. 1985 Jan;31(1):537-539 PMID: 9895517
  2. Design and characterization of electrochromic membrane probes.
    J Biochem Biophys Methods. 1982 Aug;6(3):243-60 PMID: 7130621
  3. Charge shift optical probes of membrane potential. Theory.
    Biochemistry. 1978 Sep 19;17(19):4065-71 PMID: 708694
  4. Spectra, membrane binding, and potentiometric responses of new charge shift probes.
    Biochemistry. 1985 Oct 8;24(21):5749-55 PMID: 4084490
  5. Real-time optical mapping of neuronal activity: from single growth cones to the intact mammalian brain.
    Annu Rev Neurosci. 1985;8:263-305 PMID: 3885828
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(88)83147-3
Published
1988-05-00
Pages
665-70
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1330244
Subset
IM
Grants
NIGMS NIH HHS · GM 35063 · United States
External Links
PubMed source DOI: 10.1016/S0006-3495(88)83147-3 PMC Full Text View journal details
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