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PMID: 3384983 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Degree of differentiation in colorectal adenocarcinomas: a multivariate analysis of the influence on survival.

Journal of clinical pathology ·Vol. 41 ·No. 5 ·1988-05-00 ·Pages 532-7

Halvorsen TB, Seim E

Abstract

Three hundred and sixty eight resected colorectal adenocarcinomas were graded (WHO) retrospectively and the results correlated with estimated length of patient survival. In 30 (82%) of the tumours more than one degree of differentiation was found. Histological grade significantly influenced survival time when other explanatory variables such as tumour site and stage, age, and sex were adjusted for. The results suggested that three degrees of differentiation (well, moderate, and poor) are sufficient for the grading of colorectal carcinomas, and that grading should be based on the predominating degree of differentiation represented in the primary tumour.

MeSH Terms

Adenocarcinoma/mortality,pathology Adult Aged Aged, 80 and over Cell Transformation, Neoplastic/pathology Colonic Neoplasms/mortality,pathology Female Humans Male Middle Aged Neoplasm Staging Prognosis Rectal Neoplasms/mortality,pathology

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Halvorsen T B

Department of Pathology, Trondheim Regional and University Hospital, Norway.

Seim E

References (13)

13 references, click to expand

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Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.41.5.532

Published

1988-05-00

Pages

532-7

Language

English

Region

England

NLM ID

0376601

PMCID

PMC1141506

Subset

External Links

PubMed source DOI: 10.1136/jcp.41.5.532 PMC Full Text View journal details

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