Autoantibodies detected in rabbits hyperimmunized with group A, C, and G streptococcal vaccines.

Infection and immunity ·Vol. 18 ·No. 3 ·1977-12-00 ·Pages 624-8

Onică D, Mihalcu F, Lenkei R, Gherman M, Tudor M

Abstract

Rabbits hyperimmunized with group A, C, and G streptococcal vaccines developed autoantibodies with affinities for different tissues (smooth muscle, cytoplasmic, and myocardial antibodies) and for autologous proteins (anti-albumin and anti-immunoglobulin antibodies). The presence of anti-albumin and smooth muscle antibodies, associated with a high level of immunoglobulin, suggests the development of hepatic disorders in the hyperimmunized rabbits.

MeSH Terms

Animals Antibodies Antibodies, Anti-Idiotypic Antibodies, Bacterial Autoantibodies Bacterial Vaccines Erythrocytes/immunology Immunization, Secondary Immunoglobulin G Muscle, Smooth/immunology Rabbits Serum Albumin/immunology Streptococcus pyogenes/immunology

Chemicals

Antibodies Antibodies, Anti-Idiotypic Antibodies, Bacterial Autoantibodies Bacterial Vaccines Immunoglobulin G Serum Albumin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Onică D

Mihalcu F

Lenkei R

Gherman M

Tudor M

References (17)

17 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.18.3.624-628.1977

Published

1977-12-00

Pages

624-8

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC421281

Subset

External Links

PubMed source DOI: 10.1128/iai.18.3.624-628.1977 PMC Full Text View journal details

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Autoantibodies detected in rabbits hyperimmunized with group A, C, and G streptococcal vaccines.

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