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PMID: 3377468 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Pilot study of recombinant interferon alpha-2a for treatment of infants with bronchiolitis induced by respiratory syncytial virus.

Antimicrobial agents and chemotherapy ·Vol. 32 ·No. 4 ·1988-04-00 ·Pages 589-91

Portnoy J, Hicks R, Pacheco F, Olson L

Abstract

Eleven children with bronchiolitis induced by respiratory syncytial virus received 10,000 to 70,000 U of recombinant interferon alpha-2a per kg of body weight per day. None developed signs of toxicity, and all but one developed an antiviral state following treatment. Interferon alpha-2a appears to be safe for infants with bronchiolitis. Its efficacy for the treatment of this condition remains to be determined.

MeSH Terms
Antibodies/analysis Biological Assay Bronchiolitis, Viral/microbiology,therapy Humans Infant Interferon Type I/analysis,immunology,therapeutic use Pilot Projects Respiratory Syncytial Viruses/drug effects Respirovirus Infections/therapy
Chemicals
Antibodies Interferon Type I
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Portnoy J
Section of Allergy/Immunology Diseases, Children's Mercy Hospital, Kansas City, Missouri.
Hicks R
Pacheco F
Olson L
References (11)
11 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.32.4.589
Published
1988-04-00
Pages
589-91
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172227
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.32.4.589 PMC Full Text View journal details
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