Home LiteratureArticle Details
PMID: 336540 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cellular source of interferons in the circulation of mice with delayed hypersensitivity.

Infection and immunity ·Vol. 18 ·No. 2 ·1977-11-00 ·Pages 283-90

Sonnenfeld G, Salvin SB, Youngner JS

Abstract

The cellular origins of type I and type II interferons released into the circulation of mice with delayed hypersensitivity were investigated. We determined the effect of treatment with various immunosuppressive agents, including cyclophosphamide, cycloheximide, antithymocyte serum, and whole-body X-irradiation, on the release of interferons after intravenous injection of specific (old tuberculin) or nonspecific (lipopolysaccharide) stimuli. The results suggest that (i) a heterogeneous population of lymphocytes (T and B cells) produces type II interferon, (ii) type I interferon is produced by a different cell population, and (iii) type II interferon is produced de novo after challenge with old tuberculin of mice sensitized with Mycobacterium bovis BCG.

MeSH Terms
Antilymphocyte Serum/pharmacology B-Lymphocytes/metabolism BCG Vaccine Cycloheximide/pharmacology Cyclophosphamide/pharmacology Hypersensitivity, Delayed/metabolism Interferons/biosynthesis Mycobacterium bovis T-Lymphocytes/immunology,metabolism Tuberculin X-Rays
Chemicals
Antilymphocyte Serum BCG Vaccine Tuberculin Cyclophosphamide Interferons Cycloheximide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sonnenfeld G
Salvin S B
Youngner J S
References (20)
20 references, click to expand
  1. T and B lymphocytes in the regulation of delayed hypersensitivity.
    J Immunol. 1976 Nov;117(5 Pt.2):2014-20 PMID: 62803
  2. Evidence for a B-cell -like helper function in mixed lymphocyte culture between immunocompetent thymus cells.
    J Exp Med. 1975 Feb 1;141(2):360-73 PMID: 123000
  3. Migration inhibitory factor and type II interferon in the circulation of mice sensitized with mycobacterial components.
    J Immunol. 1975 Jan;114(1 Pt 2):354-9 PMID: 1090652
  4. Specificity and nature of binding of antimacrophage serum.
    Immunology. 1972 Mar;22(3):431-9 PMID: 4112737
  5. Cell interactions in the immune response in vitro. V. Specific collaboration via complexes of antigen and thymus-derived cell immunoglobulin.
    J Exp Med. 1972 Oct 1;136(4):737-60 PMID: 4115708
  6. Semi-micro, dye-binding assay for rabbit interferon.
    Appl Microbiol. 1971 Apr;21(4):723-5 PMID: 4325022
  7. Effect of antilymphocytic serum on circulating interferon in mice as a function of the inducer.
    Nat New Biol. 1971 Feb 17;229(7):212-4 PMID: 4325471
  8. Control of interferon synthesis: effect of diethylaminoethyl-dextran on induction by polyinosinic-polycytidylic acid.
    J Virol. 1972 Oct;10(4):614-21 PMID: 4343544
  9. Production and properties of migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity.
    J Immunol. 1973 Dec;111(6):1914-22 PMID: 4356326
  10. The biological activities of soluble lymphocyte products.
    Clin Exp Immunol. 1972 Jan;10(1):1-23 PMID: 4552817
  11. The production of migration inhibition factor by B and T cells of the guinea pig.
    J Exp Med. 1973 Oct 1;138(4):784-97 PMID: 4582841
  12. T cell control of antibody production.
    Contemp Top Immunobiol. 1974;3:1-40 PMID: 4598645
  13. Studies on mediator production by highly purified human T and B lymphocytes.
    J Exp Med. 1974 Nov 1;140(5):1303-16 PMID: 4608321
  14. Selective depletion of lymphoid tissue by cyclophosphamide.
    Clin Exp Immunol. 1972 Feb;10(2):285-96 PMID: 5046868
  15. Nature and mode of action of antilymphocytic antiserum.
    Proc Natl Acad Sci U S A. 1966 Oct;56(4):1130-7 PMID: 5339289
  16. Inter- feron synthesis in x-irradiated animals. 3. The high radiosensitivity of myxovirus-induced circulating interferon production.
    Proc Soc Exp Biol Med. 1969 May;131(1):36-41 PMID: 5770121
  17. Influence of inhibitors of protein synthesis on interferon formation in mice.
    Virology. 1965 Dec;27(4):541-50 PMID: 5855570
  18. Delayed hypersensitivity in the development of circulating antibody; the effect of x-irradiation.
    J Exp Med. 1959 Apr 1;109(4):325-38 PMID: 13641560
  19. A new model to study hematopoietic transplantation antigens.
    J Immunol. 1961 Jun;86:638-45 PMID: 13691866
  20. Migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity.
    Infect Immun. 1973 Jan;7(1):68-75 PMID: 16558073
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.18.2.283-290.1977
Published
1977-11-00
Pages
283-90
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421228
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.18.2.283-290.1977 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2