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PMID: 336522 Published · ppublish English Comparative Study Journal Article

Protection of mice against malaria by a killed vaccine: differences in effectiveness against P. yoelii and P. berghei.

Immunology ·Vol. 33 ·No. 4 ·1977-10-00 ·Pages 507-15

Playfair JH, De Souza JB, Cottrell BJ

Abstract

(C57BI x Balb/c)F1 mice are normally killed by a strain of the malaria P. yoelii, but they can be fully protected by a killed vaccine. The best results were obtained with saponin-lysed parasitized cells subsequently fixed with 0-06% formalin and injected intravenously with the adjuvant B. pertussis, though good protection was also obtained without the adjuvant. The protection was specific and at least partly mediated by a serum factor. A similar regime gives little or no protection against P. berghei. Possible reasons for this difference are considered and the mechanisms by which vaccination works against P. yoelii are discussed.

MeSH Terms
Animals Bacterial Vaccines Immunization, Passive Malaria/prevention & control Mice Plasmodium/immunology Plasmodium berghei/immunology Species Specificity Vaccination
Chemicals
Bacterial Vaccines
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Playfair J H
De Souza J B
Cottrell B J
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22 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1977-10-00
Pages
507-15
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1445387
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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