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PMID: 3357892 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Identification of human immunodeficiency virus subtypes with distinct patterns of sensitivity to serum neutralization.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 8 ·1988-04-00 ·Pages 2815-9

Cheng-Mayer C, Homsy J, Evans LA, Levy JA

Abstract

The human immunodeficiency virus (HIV) type 1 displays a high degree of genetic variation, especially in the glycoprotein (gp120) domain of the envelope gene. To determine whether this genomic heterogeneity leads to the expression of independent HIV subtypes, 12 sera from HIV type 1 antibody-positive individuals were tested for their ability to neutralize 20 HIV isolates of various origins. Four distinct HIV subtypes with different sensitivity to serum neutralization were identified. These results suggest that a finite number of HIV subtypes exist and that the combined use of selected HIV isolates representing several subtypes may be necessary for the development of an effective vaccine.

MeSH Terms
HIV/classification,immunology Kinetics Molecular Weight Neutralization Tests Retroviridae Proteins/analysis,immunology Serotyping Viral Envelope Proteins/immunology
Chemicals
Retroviridae Proteins Viral Envelope Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cheng-Mayer C
Department of Medicine, University of California, San Francisco 94143.
Homsy J
Evans L A
Levy J A
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34 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.8.2815
Published
1988-04-00
Pages
2815-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC280090
Subset
IM
Grants
NIAID NIH HHS · AI-24499 · United States
External Links
PubMed source DOI: 10.1073/pnas.85.8.2815 PMC Full Text View journal details
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