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PMID: 3348607 Published · ppublish English Journal Article

Enterohepatic circulation of NY-198, a new difluorinated quinolone, in rats.

Antimicrobial agents and chemotherapy ·Vol. 32 ·No. 1 ·1988-01-00 ·Pages 156-7

Saito A, Nagata O, Takahara Y, Okezaki E, Yamada T, Ito Y

Abstract

Enterohepatic circulation of NY-198 in rats was studied. NY-198 glucuronide in the bile was rapidly hydrolyzed to NY-198 by the intestinal contents. Hydrolyzed and parent NY-198 in the bile were reabsorbed from the intestine. The amount of NY-198 in enterohepatic circulation was 59.8% of that excreted in the bile.

MeSH Terms
Animals Anti-Infective Agents/pharmacokinetics Bile/metabolism Enterohepatic Circulation Fluoroquinolones Intestinal Mucosa/metabolism Liver/metabolism Male Quinolines/pharmacokinetics Quinolones Rats Rats, Inbred Strains
Chemicals
Anti-Infective Agents Fluoroquinolones Quinolines Quinolones lomefloxacin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Saito A
College of Medical Technology, Hokkaido University, Sapporo, Japan.
Nagata O
Takahara Y
Okezaki E
Yamada T
Ito Y
References (4)
4 references, click to expand
  1. IUPAC Commission on the Nomenclature of Organic Chemistry (CON) and IUPAC-IUB Commission on Biochemical Nomenclature (CBN). The nomenclature of cyclitols. Tentative rules.
    Biochem J. 1969 Mar;112(1):17-28 PMID: 5774497
  2. Excretion and re-excretion of a broad-spectrum penicillin in bile.
    Br J Pharmacol Chemother. 1961 Dec;17:414-9 PMID: 13917127
  3. Observations on the metabolic disposition of chloramphenicol (chloromycetin) in the rat.
    J Pharmacol Exp Ther. 1952 Apr;104(4):452-8 PMID: 14918067
  4. In vitro and in vivo activity of NY-198, a new difluorinated quinolone.
    Antimicrob Agents Chemother. 1987 Jun;31(6):854-9 PMID: 3476021
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.32.1.156
Published
1988-01-00
Pages
156-7
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172121
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.32.1.156 PMC Full Text View journal details
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