G6PD Viangchan: a new glucose 6-phosphate dehydrogenase variant from Laos.

Human genetics ·Vol. 78 ·No. 1 ·1988-01-00 ·Pages 98-9

Poon MC, Hall K, Scott CW, Prchal JT

Abstract

We describe a previously unreported glucose-6-phosphate dehydrogenase-(G6PD) variant. G6PD Viangchan was found in a Laotian immigrant to Calgary, Canada, and was characterized by severe enzyme deficiency, normal electrophoretic mobility, increased pH optimum, and abnormal kinetics for the natural substrates G6PD and NADP, as well as the artificial substrates 2-deoxy G6PD and deamino NADP. The inhibition constant for NADPH was decreased. The subject has no evidence suggesting chronic or episodic hemolysis.

MeSH Terms

Child Genetic Variation Glucosephosphate Dehydrogenase/genetics Humans Kinetics Laos Male

Chemicals

Glucosephosphate Dehydrogenase

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Poon M C

Division of Hematology, University of Calgary, Alberta, Canada.

Hall K

Scott C W

Prchal J T

References (5)

5 references, click to expand

Biochemical variants of glucose-6-phosphate dehydrogenase giving rise to congenital nonspherocytic hemolytic disease.
Blood. 1968 Feb;31(2):131-50 PMID: 5643703
Hemolytic anemia and G6PD deficiency.
Science. 1973 Feb 9;179(4073):532-7 PMID: 4405605
G-6-PD variants in Chinese in Thailand.
Southeast Asian J Trop Med Public Health. 1980 Jun;11(2):250-5 PMID: 7434076
Embryonic zeta-globin chains in adults: a marker for alpha-thalassemia-1 haplotype due to a greater than 17.5-kb deletion.
N Engl J Med. 1986 Jan 9;314(2):76-9 PMID: 3941693
The removal of leukocytes and platelets from whole blood.
J Lab Clin Med. 1976 Aug;88(2):328-33 PMID: 956688

Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00291246

Published

1988-01-00

Pages

98-9

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00291246 View journal details

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G6PD Viangchan: a new glucose 6-phosphate dehydrogenase variant from Laos.

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