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PMID: 3317826 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Evolutionary and somatic selection of the antibody repertoire in the mouse.

Science (New York, N.Y.) ·Vol. 238 ·No. 4830 ·1987-11-20 ·Pages 1088-94

Rajewsky K, Förster I, Cumano A

Abstract

The repertoire of antibody variable (V) regions has been subject to evolutionary selection, affecting both the diversity of V region genes in the germline and their expression in the B lymphocyte population and its subsets. In ontogeny, contact with an antigen leads to the expansion of B cells expressing antibodies complementary to it. In a defined phase of B cell differentiation, new sets of V regions are generated from the existing repertoire through somatic hypermutation. Cells carrying advantageous antibody mutants are selected into the memory compartment and produce a stable secondary response upon reexposure to the antigen.

MeSH Terms
Animals Antibodies/genetics Antibody Diversity B-Lymphocytes/physiology Biological Evolution Genes, Immunoglobulin Genes, Switch Immunity Immunoglobulin Isotypes/genetics Immunoglobulin Variable Region/genetics Mice Mutation Selection, Genetic
Chemicals
Antibodies Immunoglobulin Isotypes Immunoglobulin Variable Region
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rajewsky K
Institute for Genetics, University of Cologne, Köln, FRG.
Förster I
Cumano A
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.3317826
Published
1987-11-20
Pages
1088-94
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Databases
GENBANK
M18481, M18482, M18483, M18484, M18485, M18486, M18487, M18488, M18489, M18490, M18491, M18492, M18493, M18494, M18495, M18496, M18497, M18498
External Links
PubMed source DOI: 10.1126/science.3317826 View journal details
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