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PMID: 3317825 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Development of the primary antibody repertoire.

Science (New York, N.Y.) ·Vol. 238 ·No. 4830 ·1987-11-20 ·Pages 1079-87

Alt FW, Blackwell TK, Yancopoulos GD

Abstract

The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.

MeSH Terms

Animals Antibodies/genetics Antibody Diversity B-Lymphocytes/physiology Gene Expression Regulation Genes, Immunoglobulin Humans Immunoglobulin Variable Region/genetics

Chemicals

Antibodies Immunoglobulin Variable Region

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Alt F W

Department of Biochemistry, College of Physicians and Surgeons of Columbia University, New York, NY 10032.

Blackwell T K

Yancopoulos G D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.3317825

Published

1987-11-20

Pages

1079-87

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAID NIH HHS · AI-20047 · United States

NCI NIH HHS · CA-40427 · United States

External Links

PubMed source DOI: 10.1126/science.3317825 View journal details

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Development of the primary antibody repertoire.

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