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PMID: 3298542 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inhibitory effect of a protease inhibitor, leupeptin, on the development of influenza pneumonia, mediated by concomitant bacteria.

The Journal of general virology ·Vol. 68 ( Pt 7) ·1987-07-00 ·Pages 2039-41

Tashiro M, Klenk HD, Rott R

Abstract

The protease inhibitor leupeptin prevented multiple step replication of an influenza virus (A/swine/1976/31, H1N1) mediated by staphylococcal proteases. It also suppressed virus replication and development of fatal pneumonia in mice co-infected with the virus and Staphylococcus aureus.

MeSH Terms

Animals Endopeptidases/metabolism Hemagglutinin Glycoproteins, Influenza Virus Hemagglutinins, Viral/metabolism Influenza A virus/physiology Leupeptins/pharmacology Metalloendopeptidases Mice Oligopeptides/pharmacology Orthomyxoviridae Infections/complications Pneumonia, Staphylococcal/etiology,prevention & control Protease Inhibitors Protein Processing, Post-Translational/drug effects Staphylococcus aureus/enzymology Virus Replication/drug effects

Chemicals

Hemagglutinin Glycoproteins, Influenza Virus Hemagglutinins, Viral Leupeptins Oligopeptides Protease Inhibitors Endopeptidases Metalloendopeptidases auR protein, Staphylococcus aureus leupeptin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Tashiro M

Klenk H D

Rott R

Article Info

Journal

The Journal of general virology

Abbr.

J Gen Virol

ISSN

0022-1317

DOI

10.1099/0022-1317-68-7-2039

Published

1987-07-00

Pages

2039-41

Language

English

Region

England

NLM ID

0077340

Subset

External Links

PubMed source DOI: 10.1099/0022-1317-68-7-2039 View journal details

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Inhibitory effect of a protease inhibitor, leupeptin, on the development of influenza pneumonia, mediated by concomitant bacteria.

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