Home LiteratureArticle Details
PMID: 3297768 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Neuropeptides in pelvic afferent pathways.

Experientia ·Vol. 43 ·No. 7 ·1987-07-15 ·Pages 801-13

de Groat WC

Abstract

Neurochemical and pharmacological experiments have raised the possibility that several neuropeptides including, vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine amide (PHI), substance P, calcitonin gene-related peptide (CGRP), neurokinin A, cholecystokinin (CCK) and opioid peptides may be transmitters in afferent pathways to the pelvic viscera. These substances are widely distributed in: 1) nerve fibers in the pelvic organs, 2) visceral afferent neurons in the lumbosacral dorsal root ganglia and 3) at sites of afferent termination in the spinal cord. Double staining immunocytochemical techniques have shown that more than one peptide can be localized in individual visceral afferent neurons and that neuronal excitatory (VIP, substance P, CCK) and inhibitory peptides (leucine enkephalin) can coexist in the same afferent cell. Studies with the neurotoxin, capsaicin, indicate that peptidergic afferent pathways are involved in the initiation of central autonomic reflexes as well as peripheral axon reflexes which modulate smooth muscle activity, facilitate transmission in automatic ganglia and trigger local inflammatory responses.

MeSH Terms
Afferent Pathways/cytology,physiology Animals Efferent Pathways/cytology,physiology Ganglia, Spinal/cytology,physiology Humans Neuropeptides/analysis,physiology Pelvis/innervation Spinal Cord/cytology,physiology
Chemicals
Neuropeptides
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
de Groat W C
References (113)
113 references, click to expand
  1. Segmental distribution and central projections of renal afferent fibers in the cat studied by transganglionic transport of horseradish peroxidase.
    J Comp Neurol. 1983 May 10;216(2):162-74 PMID: 6863600
  2. Organization of the sacral parasympathetic reflex pathways to the urinary bladder and large intestine.
    J Auton Nerv Syst. 1981 Apr;3(2-4):135-60 PMID: 6268684
  3. Does cholecystokinin-like immunoreactivity in rat primary sensory neurons represent calcitonin gene-related peptide?
    Neurosci Lett. 1986 Aug 4;68(3):305-10 PMID: 3528932
  4. Distribution of galanin immunoreactivity in the central nervous system and the responses of galanin-containing neuronal pathways to injury.
    Neuroscience. 1985 Oct;16(2):343-54 PMID: 2417156
  5. Distribution of galanin immunoreactivity in the genitourinary tract of man and rat.
    Peptides. 1986 Jan-Feb;7(1):5-10 PMID: 2423990
  6. Enkephalin-containing neurons visualized in spinal cord cell cultures.
    Science. 1978 Aug 4;201(4354):467-9 PMID: 351811
  7. Calcitonin gene-related peptide (CGRP) in the female rat urogenital tract.
    Peptides. 1985 Sep-Oct;6(5):809-15 PMID: 2417202
  8. Systemic capsaicin treatment impairs the micturition reflex in the rat.
    Br J Pharmacol. 1984 Dec;83(4):935-41 PMID: 6518344
  9. Studies on the distribution of PHI in mammals.
    Peptides. 1984 Mar-Apr;5(2):261-6 PMID: 6548022
  10. Prodynorphin opioid peptides in small somatosensory primary afferents of guinea pig.
    Neurosci Lett. 1985 Aug 5;58(3):347-52 PMID: 2864670
  11. Immunocytochemical demonstration of beta-endorphin and beta-lipotropin in cultured human spinal ganglion neurons.
    Brain Res. 1984 Jun 18;304(1):192-6 PMID: 6331581
  12. Identification of neuropeptides in pelvic and pudendal nerve afferent pathways to the sacral spinal cord of the cat.
    J Comp Neurol. 1986 Jul 1;249(1):117-32 PMID: 2426310
  13. The effects of topical capsaicin on rat urinary bladder motility in vivo.
    Eur J Pharmacol. 1984 Aug 3;103(1-2):41-50 PMID: 6207035
  14. Co-localization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous, vascular and visceral sensory neurons of guinea pigs.
    Neurosci Lett. 1985 Jun 12;57(2):125-30 PMID: 2412189
  15. Immunohistochemical studies on the effect of capsaicin on spinal and medullary peptide and monoamine neurons using antisera to substance P, gastrin/CCK, somatostatin, VIP, enkephalin, neurotensin and 5-hydroxytryptamine.
    J Neurocytol. 1981 Dec;10(6):963-80 PMID: 6171625
  16. A VIP/PHI-containing pathway links urinary bladder and sacral spinal cord.
    Peptides. 1986;7 Suppl 1:205-19 PMID: 3529051
  17. Sensory innervation of reproductive organs.
    Prog Brain Res. 1986;67:115-31 PMID: 3823468
  18. Ontogeny of the peptidergic system in the rat spinal cord: immunohistochemical analysis.
    J Comp Neurol. 1982 Jun 10;208(1):54-66 PMID: 6181101
  19. Functional properties of spinal visceral afferents supplying abdominal and pelvic organs, with special emphasis on visceral nociception.
    Prog Brain Res. 1986;67:87-114 PMID: 3823484
  20. Multiple tachykinins (neurokinin A, neuropeptide K and substance P) in capsaicin-sensitive sensory neurons in the guinea-pig.
    Regul Pept. 1985 Dec;13(1):1-19 PMID: 2418471
  21. Substance P in primary afferent neurons of the female rat reproductive system.
    Naunyn Schmiedebergs Arch Pharmacol. 1984 Jul;326(4):343-6 PMID: 6207443
  22. Calcitonin and calcitonin gene-related peptide enhance calcium-dependent potentials.
    Brain Res. 1986 Mar 5;367(1-2):346-50 PMID: 2421835
  23. Substance P as an excitatory transmitter of primary afferent neurons in guinea-pig sympathetic ganglia.
    Neuroscience. 1982;7(9):2025-37 PMID: 6183613
  24. Coexistence of peptide immunoreactivity in sensory neurons of the cat.
    Neuroscience. 1985 Nov;16(3):683-90 PMID: 2419783
  25. The distribution of visceral primary afferents from the pelvic nerve to Lissauer's tract and the spinal gray matter and its relationship to the sacral parasympathetic nucleus.
    J Comp Neurol. 1981 Sep 20;201(3):415-40 PMID: 7276258
  26. Location and morphology of parasympathetic preganglionic neurons in the sacral spinal cord of the cat revealed by retrograde axonal transport of horseradish peroxidase.
    J Comp Neurol. 1980 Sep 1;193(1):265-81 PMID: 7430430
  27. The distribution and origin of VIP in the spinal cord of six mammalian species.
    Peptides. 1984 Mar-Apr;5(2):201-7 PMID: 6433328
  28. Substance P-immunoreactive peripheral branches of sensory neurons innervate guinea pig sympathetic neurons.
    Proc Natl Acad Sci U S A. 1982 Mar;79(5):1668-72 PMID: 6175970
  29. Vasoactive intestinal polypeptide and substance P in primary afferent pathways to the sacral spinal cord of the cat.
    J Comp Neurol. 1985 Nov 15;241(3):327-47 PMID: 2418069
  30. Immunoreactive vasoactive intestinal polypeptide is concentrated in the sacral spinal cord: a possible marker for pelvic visceral afferent fibers.
    Somatosens Res. 1983;1(1):69-82 PMID: 6679914
  31. Distribution of capsaicin-sensitive nerve fibres containing immunoreactive substance P in cutaneous and visceral tissues of the rat.
    Neurosci Lett. 1982 Aug 31;31(3):253-7 PMID: 6182512
  32. Vasoactive intestinal polypeptide facilitates muscarinic transmission in mammalian sympathetic ganglia.
    Neurosci Lett. 1984 Nov 23;52(1-2):19-23 PMID: 6152040
  33. Functional evidence for the existence of a capsaicin-sensitive innervation in the rat urinary bladder.
    J Pharm Pharmacol. 1986 Jun;38(6):446-51 PMID: 2873221
  34. Capsaicin treatment decreases tissue levels of neurokinin A-like immunoreactivity in the guinea pig.
    Acta Physiol Scand. 1985 May;124(1):129-31 PMID: 2990165
  35. Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P.
    Neuroscience. 1985 Aug;15(4):1227-37 PMID: 2413390
  36. Peptidergic innervation of the human male genital tract.
    J Urol. 1983 Aug;130(2):386-91 PMID: 6192258
  37. Neurokinin A-like immunoreactivity in rat primary sensory neurons; coexistence with substance P.
    Histochemistry. 1985;83(1):37-9 PMID: 2412987
  38. Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section.
    Brain Res. 1976 Aug 13;112(2):407-12 PMID: 821584
  39. Substance P-containing primary sensory neurons projecting to the inferior mesenteric ganglion: evidence from combined retrograde tracing and immunohistochemistry.
    Neuroscience. 1982 Mar;7(3):647-54 PMID: 6175922
  40. Vasoactive intestinal polypeptide excites mammalian dorsal horn neurons both in vivo and in vitro.
    Brain Res. 1982 Jul 8;243(1):158-64 PMID: 7116152
  41. The origin of VIP-containing nerves in the urinary bladder of rat.
    Peptides. 1984 Mar-Apr;5(2):219-23 PMID: 6382192
  42. The location and morphology of preganglionic neurons and the distribution of visceral afferents from the rat pelvic nerve: a horseradish peroxidase study.
    J Comp Neurol. 1984 Jun 20;226(2):238-45 PMID: 6736301
  43. Origin and distribution of neuropeptide Y-, vasoactive intestinal polypeptide-and substance P-containing nerve fibers in the urinary bladder of the rat.
    Cell Tissue Res. 1985;239(1):141-6 PMID: 2578316
  44. Localization of immunoreactive dynorphin in neurons cultured from spinal cord and dorsal root ganglia.
    Proc Natl Acad Sci U S A. 1982 Nov;79(21):6742-6 PMID: 6128736
  45. Horseradish peroxidase tracing of visceral efferent and primary afferent pathways in the cat's sacral spinal cord using benzidine processing.
    Neurosci Lett. 1978 Nov;10(1-2):103-8 PMID: 19605264
  46. Peripheral peptide neurons: distribution, axonal transport, and some aspects on possible function.
    Adv Biochem Psychopharmacol. 1980;22:25-36 PMID: 6156578
  47. Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo.
    Nature. 1980 Jul 10;286(5769):155-7 PMID: 6157098
  48. PHI-like immunoreactivity co-locates with the VIP-containing system in human lumbosacral spinal cord.
    Neurosci Lett. 1984 May 4;46(2):191-6 PMID: 6377123
  49. A VIP-containing system concentrated in the lumbosacral region of human spinal cord.
    Nature. 1983 Sep 8-14;305(5930):143-5 PMID: 6193428
  50. Three-dimensional distribution of substance P-like immunoreactivity in the urinary bladder of rat.
    J Neural Transm. 1985;63(3-4):209-22 PMID: 2415674
  51. Peptide-containing nerves in human urinary bladder.
    Urology. 1984 Oct;24(4):353-7 PMID: 6207653
  52. The motor effect of the capsaicin-sensitive inhibitory innervation of the rat ureter.
    Eur J Pharmacol. 1986 Jul 31;126(3):333-6 PMID: 3019720
  53. Spinal cord projections and neuropeptides in visceral afferent neurons.
    Prog Brain Res. 1986;67:165-87 PMID: 3823470
  54. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing.
    Nature. 1983 Jul 14-20;304(5922):129-35 PMID: 6346105
  55. The role of neuropeptides in the regulation of the micturition reflex.
    J Auton Pharmacol. 1986 Jun;6(2):133-62 PMID: 2426274
  56. The spinal distribution of sympathetic preganglionic and visceral primary afferent neurons that send axons into the hypogastric nerves of the cat.
    J Comp Neurol. 1986 Jan 1;243(1):23-40 PMID: 3950078
  57. Distribution of VIP neurons in the peripheral and central nervous system.
    Endocrinol Jpn. 1980 Dec;27 Suppl 1:23-30 PMID: 7014205
  58. Depolarization and muscarinic excitation induced in a sympathetic ganglion by vasoactive intestinal polypeptide.
    Science. 1985 Aug 30;229(4716):879-81 PMID: 3895438
  59. Peptidergic (substance P) nerves in the genito-urinary tract.
    Neuroscience. 1978;3(4-5):419-25 PMID: 355925
  60. Neurotransmitters and CNS disease. Pain.
    Lancet. 1982 Nov 13;2(8307):1084-8 PMID: 6182432
  61. Studies on the location and release of cholecystokinin and vasoactive intestinal peptide in rat and cat spinal cord.
    Brain Res. 1982 Jun 24;242(2):279-90 PMID: 6896838
  62. Blockade of slow excitatory post-synaptic potential by substance P antagonists in guinea-pig sympathetic ganglia.
    J Physiol. 1985 Apr;361:115-30 PMID: 2580973
  63. Central distribution of afferent and efferent components of the pudendal nerve in cat.
    J Comp Neurol. 1984 Jan 1;222(1):38-46 PMID: 6699201
  64. The human spinal cord: substance P and methionine-enkephalin immunoreactivity.
    J Neurosci. 1982 Oct;2(10):1369-86 PMID: 6181229
  65. Opiate analgesics inhibit substance P release from rat trigeminal nucleus.
    Nature. 1977 Aug 11;268(5620):549-51 PMID: 18681
  66. Localisation and measurement of VIP in the genitourinary system of man and animals.
    Peptides. 1984 Mar-Apr;5(2):225-30 PMID: 6382193
  67. Vasoactive intestinal polypeptide occurs in nerves of the female genitourinary tract.
    Science. 1977 Sep 30;197(4311):1374-5 PMID: 897673
  68. Capsaicin-induced substance P release and sensory control of vascular permeability in the guinea-pig ureter.
    Neurosci Lett. 1983 Oct 31;41(1-2):167-72 PMID: 6196695
  69. Peptidergic neurones.
    Nature. 1980 Apr 10;284(5756):515-21 PMID: 6154244
  70. Parasympathetic preganglionic neurons and visceral primary afferents in monkey sacral spinal cord revealed following application of horseradish peroxidase to pelvic nerve.
    J Comp Neurol. 1983 May 1;216(1):36-52 PMID: 6306063
  71. Calcitonin gene-related peptide immunoreactivity in afferent neurons supplying the urinary tract: combined retrograde tracing and immunohistochemistry.
    Neuroscience. 1986 Jul;18(3):727-47 PMID: 2427972
  72. The distribution within the spinal cord of visceral primary afferent axons carried by the lumbar colonic nerve of the cat.
    Brain Res. 1986 Nov 19;398(1):11-7 PMID: 3801883
  73. The role of the capsaicin-sensitive innervation of the rat urinary bladder in the activation of micturition reflex.
    Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar;332(3):276-83 PMID: 3713873
  74. Peptide neurons in peripheral tissues including the urinary tract: immunohistochemical studies.
    Acta Pharmacol Toxicol (Copenh). 1978;43 Suppl 2:79-89 PMID: 362819
  75. Immunoreactive dynorphin B in sacral primary afferent fibers of the cat.
    J Neurosci. 1986 Jan;6(1):127-33 PMID: 2418172
  76. Substance P-like immunoreactivity in nerves associated with the vascular system of guinea-pigs.
    Neuroscience. 1982 Feb;7(2):447-59 PMID: 6176910
  77. Primary sensory afferents in the inferior mesenteric ganglion and related nerves of the guinea pig. An experimental study with anterogradely transported wheat germ agglutinin-horseradish peroxidase conjugate.
    J Auton Nerv Syst. 1986 Feb;15(2):179-90 PMID: 2420859
  78. Origins of peptide and norepinephrine nerves in the mucosa of the guinea pig small intestine.
    Gastroenterology. 1984 Apr;86(4):637-44 PMID: 6199254
  79. Evidence for the involvement of endogenous substance P in the motor effects of capsaicin on the rat urinary bladder.
    J Pharm Pharmacol. 1985 Mar;37(3):203-4 PMID: 2580073
  80. The immunohistochemical localization of nine peptides in the sacral parasympathetic nucleus and the dorsal gray commissure in rat spinal cord.
    Neuroscience. 1984 Jul;12(3):855-73 PMID: 6206440
  81. Capsaicin induced release of multiple tachykinins (substance P, neurokinin A and eledoisin-like material) from guinea-pig spinal cord and ureter.
    Neuroscience. 1986 Sep;19(1):313-9 PMID: 2431350
  82. The role of neuropeptides in the sacral autonomic reflex pathways of the cat.
    J Auton Nerv Syst. 1983 Mar-Apr;7(3-4):339-50 PMID: 6192165
  83. Substance P in renal afferent perikarya identified by retrograde transport of fluorescent dye.
    Brain Res. 1984 Dec 3;323(1):168-71 PMID: 6084536
  84. Dual capsaicin effects on ureteric motility: low dose inhibition mediated by calcitonin gene-related peptide and high dose stimulation by tachykinins?
    Acta Physiol Scand. 1986 Nov;128(3):453-65 PMID: 2431598
  85. Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat.
    Neurosci Lett. 1984 Nov 23;52(1-2):199-204 PMID: 6084836
  86. Selective facilitatory effect of vasoactive intestinal polypeptide (VIP) on muscarinic firing in vesical ganglia of the cat.
    Brain Res. 1985 Jun 17;336(2):223-34 PMID: 3891019
  87. Distribution of certain peptide-containing nerve fibres and endocrine cells in the gastrointestinal mucosa in five mammalian species.
    J Comp Neurol. 1985 Jun 15;236(3):403-22 PMID: 2414338
  88. The distribution of nine peptides in rat spinal cord with special emphasis on the substantia gelatinosa and on the area around the central canal (lamina X).
    J Comp Neurol. 1981 Sep 1;201(1):65-79 PMID: 6168670
  89. Coexistence of cholecystokinin- and substance P-like peptides in neurons of the dorsal root ganglia of the rat.
    Neurosci Lett. 1982 Nov 30;33(2):159-63 PMID: 6185888
  90. Neurokinin A depolarizes neurons of the guinea pig inferior mesenteric ganglia.
    Neurosci Lett. 1985 Sep 30;60(2):145-50 PMID: 2414698
  91. Peptidergic (vasoactive intestinal peptide) nerves in the genito-urinary tract.
    Neuroscience. 1977;2(5):751-4 PMID: 593553
  92. The organization of pudendal motoneurons and primary afferent projections in the spinal cord of the rhesus monkey revealed by horseradish peroxidase.
    J Comp Neurol. 1985 Apr 22;234(4):475-88 PMID: 3988996
  93. Activation of micturition reflex by substance P and substance K: indirect evidence for the existence of multiple tachykinin receptors in the rat urinary bladder.
    J Pharmacol Exp Ther. 1986 Jul;238(1):259-66 PMID: 2425076
  94. Preferential immunohistochemical localization of vasoactive intestinal polypeptide (VIP) in the sacral spinal cord of the cat: light and electron microscopic observations.
    J Neurosci. 1983 Nov;3(11):2183-96 PMID: 6195317
  95. Correlation of neuronal size and peptide immunoreactivity in the guinea-pig trigeminal ganglion.
    Cell Tissue Res. 1986;245(3):657-65 PMID: 2428502
  96. Immunohistochemical studies of substance P, cholecystokinin-octapeptide and somatostatin in dorsal root ganglia of the rat.
    Neuroscience. 1985 Feb;14(2):593-605 PMID: 2581169
  97. Vasoactive intestinal polypeptide (VIP) in the male genitourinary tract: concentration and motor effect.
    Invest Urol. 1981 Nov;19(3):211-3 PMID: 7298295
  98. The effect of capsaicin pretreatment on the cystometrograms of urethane anesthetized rats.
    J Urol. 1985 Apr;133(4):700-3 PMID: 3981734
  99. Effect of substance P in cat dorsal horn neurones activated by noxious stimuli.
    Brain Res. 1977 Jun 3;128(1):164-9 PMID: 871905
  100. Ureteral axon damage following subcutaneous administration of capsaicin in adult rats.
    Neurosci Lett. 1985 Jan 21;53(2):221-6 PMID: 3982708
  101. Vasoactive intestinal polypeptide in visceral afferent pathways to the sacral spinal cord of the cat.
    Neurosci Lett. 1983 Dec 11;42(3):311-6 PMID: 6664634
  102. Capsaicin and sensory neurones--a review.
    Pain. 1983 Feb;15(2):109-30 PMID: 6189047
  103. The neuropharmacology of capsaicin: review of some recent observations.
    Pharmacol Rev. 1986 Sep;38(3):179-226 PMID: 3534898
  104. Degeneration of axons in the ureteric and duodenal nerve plexuses of the adult rat following in vivo treatment with capsaicin.
    Neurosci Lett. 1981 Aug 7;25(1):19-24 PMID: 6168981
  105. Localization of cholecystokininlike immunoreactivity in the rat spinal cord, with particular reference to the autonomic innervation of the pelvic organs.
    J Comp Neurol. 1983 Jun 20;217(2):176-86 PMID: 6886051
  106. Sensory substance P-innervation of the urinary bladder: possible site of action of capsaicin in causing urine retention in rats.
    Neuroscience. 1983 Nov;10(3):861-8 PMID: 6196685
  107. Distribution and motor effect of VIP in female genital tract.
    Am J Physiol. 1981 Jan;240(1):E32-6 PMID: 7006413
  108. CGRP-immunoreactive nerves in the genitalia of the female rat originate from dorsal root ganglia T11-L3 and L6-S1: a combined immunocytochemical and retrograde tracing study.
    Neurosci Lett. 1986 Aug 15;69(1):13-8 PMID: 3528934
  109. Cholecystokinin octapeptide depolarizes guinea pig inferior mesenteric ganglion cells and facilitates nicotinic transmission.
    Neurosci Lett. 1986 Mar 14;64(3):263-8 PMID: 3008044
  110. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species.
    J Neurosci. 1984 Dec;4(12):3101-11 PMID: 6209366
  111. Neurotransmitter candidates of somatosensory primary afferent fibres.
    Neuroscience. 1983 Dec;10(4):1083-103 PMID: 6198599
  112. The capsaicin-sensitive innervation of the rat urinary bladder: further studies on mechanisms regulating micturition threshold.
    J Urol. 1986 Sep;136(3):696-700 PMID: 3735558
  113. Origin of peptide-containing fibers in the inferior mesenteric ganglion of the guinea-pig: immunohistochemical studies with antisera to substance P, enkephalin, vasoactive intestinal polypeptide, cholecystokinin and bombesin.
    Neuroscience. 1983 May;9(1):191-211 PMID: 6192355
Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01945358
Published
1987-07-15
Pages
801-13
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
Grants
NIADDK NIH HHS · AM 37241 · United States
NIMH NIH HHS · MH 30915 · United States
External Links
PubMed source DOI: 10.1007/BF01945358
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2