Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin.

FEBS letters ·Vol. 231 ·No. 2 ·1988-04-25 ·Pages 440-4

Itoh Y, Yanagisawa M, Ohkubo S, Kimura C, Kosaka T, Inoue A, Ishida N, Mitsui Y, Onda H, Fujino M

Abstract

A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.

MeSH Terms

Amino Acid Sequence Animals Base Sequence DNA/genetics Endothelin-1 Endothelins Humans Molecular Sequence Data Peptides/genetics Placenta/analysis Protein Precursors/genetics Sequence Homology, Nucleic Acid Swine/genetics

Chemicals

Endothelin-1 Endothelins Peptides Protein Precursors DNA

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Itoh Y

Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Ibaraki, Japan.

Yanagisawa M

Ohkubo S

Kimura C

Kosaka T

Inoue A

Ishida N

Mitsui Y

Onda H

Fujino M

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(88)80867-6

Published

1988-04-25

Pages

440-4

Language

English

Region

England

NLM ID

0155157

Subset

Databases

GENBANK

Y00749

External Links

PubMed source DOI: 10.1016/0014-5793(88)80867-6 View journal details

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Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin.

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