Molecular cloning of the zeta chain of the T cell antigen receptor.

Science (New York, N.Y.) ·Vol. 239 ·No. 4843 ·1988-02-26 ·Pages 1018-21

Weissman AM, Baniyash M, Hou D, Samelson LE, Burgess WH, Klausner RD

Abstract

The T cell antigen receptor is a multi-subunit receptor complex present on the surface of all mature and many developing T cells. It consists of clonotypic heterodimers noncovalently linked to five invariant chains that are encoded by four genes and referred to as the CD3 complex. The CD3 gamma, delta, and epsilon chains have been molecularly characterized. In this report the molecular cloning of a complementary DNA encoding the zeta chain of the murine T cell antigen receptor is described. The predicted protein sequence of the zeta chain suggests a structure distinct from those of any of the previously described receptor subunits.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Cell Membrane/metabolism Chromatography, High Pressure Liquid Cloning, Molecular Cyanogen Bromide DNA/genetics Electrophoresis, Polyacrylamide Gel Immunosorbent Techniques Macromolecular Substances Membrane Proteins Mice Molecular Sequence Data Molecular Weight Nucleic Acid Hybridization Peptide Fragments Protein Biosynthesis RNA, Messenger/genetics Receptors, Antigen, T-Cell/genetics T-Lymphocytes/analysis Transcription, Genetic Tumor Cells, Cultured

Chemicals

Macromolecular Substances Membrane Proteins Peptide Fragments RNA, Messenger Receptors, Antigen, T-Cell antigen T cell receptor, zeta chain DNA Cyanogen Bromide

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Weissman A M

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.

Baniyash M

Hou D

Samelson L E

Burgess W H

Klausner R D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.3278377

Published

1988-02-26

Pages

1018-21

Language

English

Region

United States

NLM ID

0404511

Subset

Databases

GENBANK

M19729

External Links

PubMed source DOI: 10.1126/science.3278377 View journal details

Analysis Services

Molecular cloning of the zeta chain of the T cell antigen receptor.

Contact

WeChat Official Account