Antimicrobial activity of synthetic magainin peptides and several analogues.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 3 ·1988-02-00 ·Pages 910-3

Zasloff M, Martin B, Chen HC

Abstract

We have previously reported the isolation of two broad-spectrum antimicrobial peptides ("magainins") from the skin of the African clawed frog Xenopus laevis. These natural peptides are active against many species of bacteria and fungi and also induce osmotic lysis of protozoa. In this report we demonstrate that synthetic magainin peptides appear to be indistinguishable from the natural products with respect to chromatographic properties and biological activity. These studies demonstrate conclusively that the magainin peptides are potent antimicrobial substances.

MeSH Terms

Animals Anti-Bacterial Agents Anti-Infective Agents/chemical synthesis,pharmacology Bacteria/drug effects Female Microbial Sensitivity Tests Paramecium/drug effects Peptide Fragments/chemical synthesis,pharmacology Saccharomyces cerevisiae/drug effects Skin/analysis Xenopus laevis

Chemicals

Anti-Bacterial Agents Anti-Infective Agents Peptide Fragments

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Zasloff M

Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.

Martin B

Chen H C

References (11)

11 references, click to expand

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Biosynthesis of peptides in the skin of Xenopus laevis: isolation of novel peptides predicted from the sequence of cloned cDNAs.
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Annu Rev Biophys Biophys Chem. 1987;16:561-81 PMID: 3297092
Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.
Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53 PMID: 3299384
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.85.3.910

Published

1988-02-00

Pages

910-3

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC279666

Subset

External Links

PubMed source DOI: 10.1073/pnas.85.3.910 PMC Full Text View journal details

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Antimicrobial activity of synthetic magainin peptides and several analogues.

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