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PMID: 3275583 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Control of endotoxin activity and interleukin-1 production through regulation of lipopolysaccharide-lipoprotein binding by a macrophage factor.

Infection and immunity ·Vol. 56 ·No. 1 ·1988-01-00 ·Pages 204-12

Warren HS, Riveau GR, de Deckker FA, Chedid LA

Abstract

Lipopolysaccharides (LPSs) extracted from gram-negative bacteria are much less active when bound to serum lipoproteins. We present evidence here that the binding of radiolabeled LPS extracted from Escherichia coli O113 and Salmonella typhimurium to lipoproteins in rabbit serum is increased 8 to 24 h after a single intravenous injection of homologous or heterologous LPS. Supernatants of activated macrophages containing interleukin-1 also stimulate increased binding. The isolated product of this binding does not induce the production of interleukin-1 by macrophages in vivo or in vitro and is unable itself to stimulate increased binding of LPS to lipoprotein. Normal rabbit sera spiked with lipoprotein fractions prepared from tolerant but not normal rabbit sera bind increased amounts of LPS. These data suggest that there may exist a self-regulated mechanism for decreasing the toxicity of LPS and the production of LPS-induced interleukin-1; this mechanism is controlled by a macrophage factor and functions through altering the binding of LPS to certain serum lipoproteins.

MeSH Terms
Animals Endotoxins/pharmacology Escherichia coli/metabolism Immune Tolerance Interleukin-1/biosynthesis Lipopolysaccharides/metabolism,pharmacology Lipoproteins/metabolism,pharmacology Macrophage Activation Macrophages/immunology,metabolism Male Protein Binding/drug effects Rabbits Salmonella typhimurium/metabolism
Chemicals
Endotoxins Interleukin-1 Lipopolysaccharides Lipoproteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Warren H S
Centre National de la Recherche Scientifique UA-579, Institut Pasteur, Paris, France.
Riveau G R
de Deckker F A
Chedid L A
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.56.1.204-212.1988
Published
1988-01-00
Pages
204-12
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC259257
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.56.1.204-212.1988 PMC Full Text View journal details
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