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题目:: Pinocchio cells: morphologically atypical immunologically heterogeneous lymphocytes induced by treatment with interleukin 2.
作者:: Paciucci(P A),Chesa(P G),Fierro(M T),Gordon(R),Konefal(R G),Glidewell(O),Holland(J F)
状态:: 发布时间1989-06-02 , 更新时间 2014-11-20
期刊:: Immunol Lett
摘要:: We describe a novel cell type, the Pinocchio cell, that appears in the peripheral blood of all patients receiving treatment with interleukin 2, up to 20,000 cells/microliter. This cell is characterized by a prominent and granular proboscis with which it attaches to tumor cells and mediates tumor cell lysis. Pinocchio cells are immunologically heterogeneous and express antigens of both T and NK cells; Pinocchio cells are adherent in culture and are more cytolytic than non-adherent cells against NK-sensitive and resistant tumor cells. Incubation of normal whole human blood for 1 h induces Pinocchio morphology of mononuclear white blood cells.
语言:: eng
DOI:

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