Graft-versus-host-related immunosuppression is induced in mixed chimeras by alloresponses against either host or donor lymphohematopoietic cells.

The Journal of experimental medicine ·Vol. 168 ·No. 6 ·1988-12-01 ·Pages 2391-6

Sykes M, Sheard MA, Sachs DH

Abstract

Graft-vs.-host (GVH)-related immunosuppression has previously been demonstrated in F1 rodent recipients of parental lymphoid cells, and has been thought to result from an immunologic attack of the donor against the host. Since all cells of such F1 recipients could potentially bear target class I MHC alloantigens, it has not previously been possible to determine precisely the target tissues responsible for development of GVH-related effects. In the present studies we have used mixed allogeneic chimeras as recipients of host or donor-strain lymphocyte inocula, and have made the surprising observation that "GVH-induced" immune unresponsiveness does not require GVH reactivity, per se, but develops in the presence of a one-way alloresponse against lymphohematopoietic cells in either the GVH or the host-versus-graft direction.

MeSH Terms

Animals Chimera Graft vs Host Reaction H-2 Antigens Immunosuppression Therapy Mice T-Lymphocytes/immunology

Chemicals

H-2 Antigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Sykes M

Transplantation Biology Section, National Cancer Institute, Bethesda, Maryland 20892.

Sheard M A

Sachs D H

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21 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.168.6.2391

Published

1988-12-01

Pages

2391-6

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2189158

Subset

External Links

PubMed source DOI: 10.1084/jem.168.6.2391 PMC Full Text View journal details

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Graft-versus-host-related immunosuppression is induced in mixed chimeras by alloresponses against either host or donor lymphohematopoietic cells.

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