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题目:: Binding of staphylococcal enterotoxin A to accessory cells is a requirement for its ability to activate human T cells.
作者:: Carlsson(R),Fischer(H),Sjögren(H O)
状态:: 发布时间1988-05-18 , 更新时间 2006-11-15
期刊:: J Immunol
摘要:: Staphylococcal enterotoxin A (SEA) activates human T cells at extremely low concentrations corresponding to 1 to 5 molecules/T cell. SEA, in contrast to other polyclonal activators, is absolutely dependent on accessory cells to interact with and activate T cells. Only cells that can bind SEA can act as accessory cells. Monocytes, B cells, and B lymphomas have these properties. Cells of the EBV-transformed B lymphoma Raji are particularly efficient as accessory cells. T cells do not bind soluble SEA. Probably the SEA molecule has to be attached to the accessory cell to become mitogenic. It is presently not known whether the T cell recognizes a molecular complex between the SEA molecule and the putative receptor moiety on the accessory cell or the SEA molecule itself modified by its binding to the accessory cell.
语言:: eng
DOI:

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