SnapShot: Ferroptosis.

Cell ·Vol. 181 ·No. 5 ·2020-00-28 ·Pages 1188-1188.e1

Hadian K, Stockwell BR

Abstract

Ferroptosis is a regulated form of cell death that occurs when phospholipids with polyunsaturated fatty acyl tails are oxidized in an iron-dependent manner. Research in recent years has uncovered complex cellular networks that induce and suppress lethal lipid peroxidation. This SnapShot provides an overview of ferroptosis-related pathways, including relevant biomolecules and small-molecule modulators regulating them.

MeSH Terms

Cell Death Ferroptosis/genetics,physiology Humans Iron/metabolism Lipid Peroxidation/physiology Oxidation-Reduction Phospholipids/metabolism

Chemicals

Phospholipids Iron

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hadian Kamyar

Assay Development and Screening Platform, Helmholtz Zentrum Mu¨nchen, Neuherberg, Germany.

Stockwell Brent R

Department of Biological Sciences, Columbia University, New York, NY 10027, USA; Department of Chemistry, Columbia University, New York, NY 10027, USA.

References (9)

9 references, click to expand

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers.
ACS Chem Biol. 2020 Feb 21;15(2):469-484 PMID: 31899616
Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis.
Nat Chem Biol. 2020 Mar;16(3):302-309 PMID: 32080622
Energy-stress-mediated AMPK activation inhibits ferroptosis.
Nat Cell Biol. 2020 Feb;22(2):225-234 PMID: 32029897
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.
Nature. 2019 Nov;575(7784):688-692 PMID: 31634900
GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling.
ACS Cent Sci. 2020 Jan 22;6(1):41-53 PMID: 31989025
FSP1 is a glutathione-independent ferroptosis suppressor.
Nature. 2019 Nov;575(7784):693-698 PMID: 31634899
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression.
Cell Res. 2020 Feb;30(2):146-162 PMID: 31949285
Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export.
Dev Cell. 2019 Dec 2;51(5):575-586.e4 PMID: 31735663
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Cell. 2017 Oct 5;171(2):273-285 PMID: 28985560

Full Text / Full Text

PMC full text available locally, click to read

Loading full text...

Article Info

Journal

Cell

Abbr.

Cell

ISSN

1097-4172

DOI

10.1016/j.cell.2020.04.039

Published

2020-00-28

Pages

1188-1188.e1

Language

English

Region

United States

NLM ID

0413066

PMCID

PMC8157339

Subset

Grants

NCI NIH HHS · P01 CA087497 · United States

NCI NIH HHS · R35 CA209896 · United States

NINDS NIH HHS · R61 NS109407 · United States

External Links

PubMed source DOI: 10.1016/j.cell.2020.04.039 PMC Full Text View journal details

Analysis Services

SnapShot: Ferroptosis.

Contact

WeChat Official Account