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PMID: 324689 Published · ppublish English Journal Article

Plasma protein binding of phenytoin and warfarin in patients undergoing renal transplantation.

Clinical pharmacokinetics ·Vol. 2 ·No. 2 ·1977-00-00 ·Pages 147-53

Odar-Cederlof I

Abstract

The plasma protein binding of phenytoin and warfarin was studied in vitro by equilibrium dialysis at 37 degrees C in plasma from patients with chronic renal disease before and after renal transplantation. The plasma protein binding of these two drugs (which is decreased in the uraemic state), increased dramatically during the first 2 to 4 postoperative days and reached values slightly below normal on the 10th to the 15th postoperative day. This increase in binding is suggested to be due to the elimination of inhibiotrs of drug albumin binding, earlier shown to be present in uraemic serum.

MeSH Terms
Adult Blood Proteins/metabolism Chronic Disease Creatinine/blood Female Humans In Vitro Techniques Kidney Transplantation Male Middle Aged Phenytoin/blood Protein Binding Serum Albumin/metabolism Time Factors Transplantation, Homologous Uremia/blood Warfarin/blood
Chemicals
Blood Proteins Serum Albumin Warfarin Phenytoin Creatinine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Odar-Cederlof I
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23 references, click to expand
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Article Info
Journal
Clinical pharmacokinetics
Abbr.
Clin Pharmacokinet
ISSN
0312-5963
DOI
10.2165/00003088-197702020-00005
Published
1977-00-00
Pages
147-53
Language
English
Region
Switzerland
NLM ID
7606849
Subset
IM
External Links
PubMed source DOI: 10.2165/00003088-197702020-00005 View journal details
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