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PMID: 323219 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

relA gene control of the synthesis of lipid A fatty acyl moieties.

Journal of bacteriology ·Vol. 130 ·No. 1 ·1977-04-00 ·Pages 114-7

Spencer A, Muller E, Cronan JE, Gross TA

Abstract

The incorporation of [14C]acetate into the fatty acid moieties of lipid A was measured during amino acid starvation of rel+ and relA strains of Escherichia coli K-12. The synthesis of the beta-hydroxymyristate and other fatty acid moieties was inhibited two- to fourfold in rel+ strains, whereas no inhibition was observed in relA strains. The fatty acid compositions of the phospholipids synthesized after amino acid starvation or rel+ and relA strains were also determined.

MeSH Terms
Acetates/metabolism Amino Acids/metabolism Escherichia coli/metabolism Fatty Acids/analysis,biosynthesis Genes Lipids/biosynthesis Myristic Acids/biosynthesis Phospholipids/analysis,biosynthesis
Chemicals
Acetates Amino Acids Fatty Acids Lipids Myristic Acids Phospholipids
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Spencer A
Muller E
Cronan J E
Gross T A
References (20)
20 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.130.1.114-117.1977
Published
1977-04-00
Pages
114-7
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC235180
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.130.1.114-117.1977 PMC Full Text View journal details
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