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PMID: 320191 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Ultraviolet induction of prophage lambda during inhibition of deoxyribonucleic acid synthesis by hydroxyurea.

Journal of bacteriology ·Vol. 129 ·No. 2 ·1977-02-00 ·Pages 698-701

Lydersen BK, Pollard EC

Abstract

Hydroxyurea inhibited synthesis of certain deoxyribonucleic acid (DNA) precursors and causes the cessation of DNA synthesis. It did not cause induction of lambda. Superinfection of an irradiated lysogen with lambdaind- could prevent induction, but the percentage of cells protected decreased as the time between irradiation and superinfection increased. The presence of hydroxyurea did not increase the time during which cells could be rescued by superinfection. The accumulation of DNA precursors after ultraviolet or ionizing radiation was not necessary for the induction of lambda prophage to occur.

MeSH Terms
Cobalt Radioisotopes Coliphages/growth & development DNA, Bacterial/biosynthesis Escherichia coli/drug effects,metabolism,radiation effects Hydroxyurea/pharmacology Lysogeny/drug effects Ultraviolet Rays Virus Replication
Chemicals
Cobalt Radioisotopes DNA, Bacterial Hydroxyurea
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lydersen B K
Pollard E C
References (12)
12 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.129.2.698-701.1977
Published
1977-02-00
Pages
698-701
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC234999
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.129.2.698-701.1977 PMC Full Text View journal details
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