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PMID: 3182082 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Hormonal modulation of sex differences in resistance to Leishmania major systemic infections.

Infection and immunity ·Vol. 56 ·No. 12 ·1988-12-00 ·Pages 3316-9

Mock BA, Nacy CA

Abstract

Differences in susceptibility to intravenously inoculated Leishmania major were observed in male and female mice of the BALB/cAnPt, DBA/2N, and DBA/2J strains and (BALB/cAnPt x DBA/2N)F1 hybrids. In all cases, males had significantly higher liver parasite burdens than females. Orchidectomy of BALB/c males resulted in a 20% decrease in the number of parasites in the liver compared with either normal or sham-gonadectomized controls. Additionally, testosterone treatment of female BALB/c mice resulted in an 88% increase in the number of liver amastigotes. These results suggest that the hormone testosterone can modulate systemic L. major infections in BALB/c mice.

MeSH Terms
Animals Female Immunity, Innate Leishmania tropica Leishmaniasis/immunology,physiopathology Liver/parasitology Male Mice Orchiectomy Sex Factors Testosterone/pharmacology
Chemicals
Testosterone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mock B A
Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892.
Nacy C A
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33 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.56.12.3316-3319.1988
Published
1988-12-00
Pages
3316-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC259743
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.56.12.3316-3319.1988 PMC Full Text View journal details
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