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PMID: 3180218 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Converting a eukaryotic transcriptional inhibitor into an activator.

Cell ·Vol. 55 ·No. 3 ·1988-11-04 ·Pages 443-6

Ma J, Ptashne M

Abstract

GAL80, an inhibitor of the yeast transcriptional activator GAL4, is converted into an activator by inserting an acidic activating sequence into it. This hybrid activator does not bind to DNA directly, but is brought to DNA by interacting with a derivative of GAL4 that interacts with both DNA and GAL80.

MeSH Terms

DNA, Fungal/metabolism Galactose/metabolism Gene Expression Regulation Genes, Fungal Recombinant Fusion Proteins/genetics,metabolism Transcription Factors/genetics,metabolism Transcription, Genetic Yeasts/genetics,metabolism

Chemicals

DNA, Fungal Recombinant Fusion Proteins Transcription Factors Galactose

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ma J

Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.

Ptashne M

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/0092-8674(88)90030-x

Published

1988-11-04

Pages

443-6

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/0092-8674(88)90030-x View journal details

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