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PMID: 3174657 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Molecular systematics of higher primates: genealogical relations and classification.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 20 ·1988-10-00 ·Pages 7627-31

Miyamoto MM, Koop BF, Slightom JL, Goodman M, Tennant MR

Abstract

We obtained 5' and 3' flanking sequences (5.4 kilobase pairs) from the psi eta-globin gene region of the rhesus macaque (Macaca mulatta) and combined them with available nucleotide data. The completed sequence, representing 10.8 kilobase pairs of contiguous noncoding DNA, was compared to the same orthologous regions available for human (Homo sapiens, as represented by five different alleles), common chimpanzee (Pan troglodytes), gorilla (Gorilla gorilla), and orangutan (Pongo pygmaeus). The nucleotide sequence for Macaca mulatta provided the outgroup perspective needed to evaluate better the relationships of humans and great apes. Pairwise comparisons and parsimony analysis of these orthologues clearly demonstrated (i) that humans and great apes share a high degree of genetic similarity and (ii) that humans, chimpanzees, and gorillas form a natural monophyletic group. These conclusions strongly favor a genealogical classification for higher primates consisting of a single family (Hominidae) with two subfamilies (Homininae for Homo, Pan, and Gorilla and Ponginae for Pongo).

MeSH Terms
Animals Base Sequence DNA/genetics Globins/genetics Gorilla gorilla/classification,genetics Hominidae/classification,genetics Humans Macaca mulatta/classification,genetics Molecular Sequence Data Pan troglodytes/classification,genetics Phylogeny Pongo pygmaeus/classification,genetics Primates/classification,genetics
Chemicals
Globins DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Miyamoto M M
Department of Zoology, University of Florida, Gainesville 32611.
Koop B F
Slightom J L
Goodman M
Tennant M R
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.20.7627
Published
1988-10-00
Pages
7627-31
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC282245
Subset
IM
Grants
NHLBI NIH HHS · R01 HL33940 · United States
Databases
GENBANK
J03818
External Links
PubMed source DOI: 10.1073/pnas.85.20.7627 PMC Full Text View journal details
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