The possible role of isoantigens in protective immunity to malaria.

Bulletin of the World Health Organization ·Vol. 57 Suppl 1 ·1979-00-00 ·Pages 135-8

Brown KN, Hills LA

Abstract

The possibility that autoimmune responses to modified red cell antigens might be involved in protective immunity to malaria was investigated in Plasmodium berghei infection of August rats. Animals rendered anaemic by phenylhydrazine treatment at the time of immunization showed significantly greater protection than rats given antigen alone, or phenylhydrazine alone. Adoptive transfer experiments indicated that this enhanced response could be transferred with spleen cells.

MeSH Terms

Animals Isoantigens/immunology Malaria/immunology,prevention & control Male Plasmodium Rats

Chemicals

Isoantigens

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Brown K N

Hills L A

References (8)

8 references, click to expand

The oxidation of pyruvate in pigeon breast muscle.
Biochem J. 1940 Mar;34(3):442-59 PMID: 16747180
Transplantation antigens per se are poor immunogens within a species.
Nature. 1978 May 4;273(5657):54-6 PMID: 692669
Alterations of red cell membranes from phenylhydrazine-treated rabbits.
Biochim Biophys Acta. 1977 Aug 15;469(1):61-73 PMID: 889825
T cells and protective immunity to Plasmodium berghei in rats.
Infect Immun. 1976 Oct;14(4):858-71 PMID: 791865
Pharmacological and biochemical actions of the hemolytic agents acetylphenylhydrazine and phenylhydrazine on monoamine oxidase in the rat.
Biochem Pharmacol. 1974 Jul 15;23(14):2045-56 PMID: 4422032
Immunity to malaria. II. Serological response of monkeys sensitized by drug-suppressed infection or by dead parasitized cells in Freund's complete adjuvant.
Exp Parasitol. 1970 Oct;28(2):318-38 PMID: 4994112
Action of malarial antibody in vitro.
Nature. 1969 Jul 26;223(5204):368-71 PMID: 4980851
Presence of HLA antigens on human reticulocytes as demonstrated by electron microscopy.
Nature. 1970 Oct 3;228(5266):67-8 PMID: 5460343

Article Info

Journal

Bulletin of the World Health Organization

Abbr.

Bull World Health Organ

ISSN

0042-9686

Published

1979-00-00

Pages

135-8

Language

English

Region

Switzerland

NLM ID

7507052

PMCID

PMC2395709

Subset

External Links

PubMed source PMC Full Text View journal details

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The possible role of isoantigens in protective immunity to malaria.

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