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PMID: 3172205 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Chloroacetaldehyde reacts with Z-DNA.

Journal of molecular biology ·Vol. 201 ·No. 4 ·1988-06-20 ·Pages 773-6

Vogt N, Marrot L, Rousseau N, Malfoy B, Leng M

Abstract

We show that chloroacetaldehyde, a chemical compound known to be reactive with unpaired adenine and cytosine residues, reacts with adenine residues (syn conformation) but not with cytosine residues (anti conformation) within Z-DNA. These modified residues are sensitive to cleavage by piperidine, which allows mapping at the single nucleotide level.

MeSH Terms
Acetaldehyde/analogs & derivatives,metabolism Base Sequence DNA/drug effects,metabolism Nucleotide Mapping Piperidines/pharmacology
Chemicals
Piperidines piperidine DNA chloroacetaldehyde Acetaldehyde
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Vogt N
Centre de Biophysique Moléculaire, Orléans, France.
Marrot L
Rousseau N
Malfoy B
Leng M
Article Info
Journal
Journal of molecular biology
Abbr.
J Mol Biol
ISSN
0022-2836
DOI
10.1016/0022-2836(88)90474-3
Published
1988-06-20
Pages
773-6
Language
English
Region
England
NLM ID
2985088R
Subset
IM
External Links
PubMed source DOI: 10.1016/0022-2836(88)90474-3 View journal details
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