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PMID: 3169995 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cell walls from avirulent variants of Histoplasma capsulatum lack alpha-(1,3)-glucan.

Infection and immunity ·Vol. 56 ·No. 11 ·1988-11-00 ·Pages 2997-3000

Klimpel KR, Goldman WE

Abstract

Cell wall composition of isogenic virulent-avirulent strain pairs of Histoplasma capsulatum varied markedly with respect to alpha-(1,3)-glucan content. When yeast cell walls were fractionated by standard techniques, the avirulent strains contained up to 1,000-fold less alpha-(1,3)-glucan than did their virulent parents. No alpha-(1,3)-glucan could be detected on the surface of the avirulent strain yeast cells if we used a mouse monoclonal antibody that recognized this polymer. A similar relationship between virulence and alpha-(1,3)-glucan has been described for Paracoccidioides brasiliensis. alpha-(1,3)-Glucan is also found in several other pathogenic fungi and may thus be an important common virulence determinant.

MeSH Terms
Antigens, Fungal/analysis Cell Wall/analysis Glucans/analysis Histoplasma/analysis,pathogenicity
Chemicals
Antigens, Fungal Glucans
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Klimpel K R
Department of Microbiology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110.
Goldman W E
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.56.11.2997-3000.1988
Published
1988-11-00
Pages
2997-3000
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC259684
Subset
IM
Grants
NIAID NIH HHS · AI25584 · United States
External Links
PubMed source DOI: 10.1128/iai.56.11.2997-3000.1988 PMC Full Text View journal details
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