The role of the left end of the H-2b haplotype in the male-specific cytotoxic T cell response.

European journal of immunology ·Vol. 9 ·No. 11 ·1979-11-00 ·Pages 913-5

von Boehmer H, Turton K, Haas W

Abstract

The male-specific cytotoxic T cell response was tested in various mouse strains. We found that priming with 10(7) nonirradiated or 2 x 10(7) X-irradiated cells (2000 Rad) was similarly effective in B6 mice. We have avoided possible allogeneic effects due to priming F1 hybrids with parental cells and tested all mice after the same time interval for generation of male-specific cytotoxic T lymphocytes in vitro. Under these conditions, we found an absolute requirement for H-2b gene products, encoded left of B, in order to see male-specific responses.

MeSH Terms

Alleles Animals Cytotoxicity, Immunologic Dose-Response Relationship, Radiation Female Genetic Code H-2 Antigens/genetics Haploidy Histocompatibility Antigens/immunology Hybridization, Genetic Male Mice Mice, Inbred A Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred CBA Mice, Inbred DBA T-Lymphocytes/immunology X-Rays

Chemicals

H-2 Antigens Histocompatibility Antigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

von Boehmer H

Turton K

Haas W

Article Info

Journal

European journal of immunology

Abbr.

Eur J Immunol

ISSN

0014-2980

DOI

10.1002/eji.1830091115

Published

1979-11-00

Pages

913-5

Language

English

Region

Germany

NLM ID

1273201

Subset

External Links

PubMed source DOI: 10.1002/eji.1830091115 View journal details

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The role of the left end of the H-2b haplotype in the male-specific cytotoxic T cell response.

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