Etretinate: management of keratoma hereditaria mutilans in four family members.

We are reporting four family members, spanning three generations, who were treated with etretinate for keratoma hereditaria mutilans. All four patients presented with mutilating keratoderma of the palms and soles, and all demonstrated remarkable benefit from the medication. In addition, in the most severely affected individual, several fingers had well-established pseudoainhums that resolved during therapy.