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PMID: 3159652 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The sheep analogue of leucocyte common antigen (LCA).

Immunology ·Vol. 55 ·No. 2 ·1985-06-00 ·Pages 347-53

Maddox JF, Mackay CR, Brandon MR

Abstract

The tissue distribution and immunochemical properties of antigens recognized by two monoclonal antibodies 1.11.32 and 1.28.124 define the sheep analogue of the leucocyte common antigen found in rat, man and mouse. Histological and immunofluorescent studies show that this antigen is found on all lymphocytes, as well as other leucocytes but is absent from non-leucocytic cells. Immunochemical data show that a series of proteins of high molecular weight (190,000-225,000) are recognized, and histological studies show the presence of this antigen on a subpopulation of fetal liver cells as early as Day 27-30 of gestation, and on all fetal thymocytes from Day 40 of gestation.

MeSH Terms

Animals Antibodies, Monoclonal/immunology Fetus/immunology Fluorescent Antibody Technique Histocompatibility Antigens/analysis Leukocyte Common Antigens Leukocytes/immunology Lymphocytes/immunology Lymphoid Tissue/immunology Mice Mice, Inbred BALB C Molecular Weight Sheep/immunology

Chemicals

Antibodies, Monoclonal Histocompatibility Antigens Leukocyte Common Antigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Maddox J F

Mackay C R

Brandon M R

References (26)

26 references, click to expand

Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
Surgical techniques for the collection of lymph from unanaesthetized sheep.
Q J Exp Physiol Cogn Med Sci. 1961 Jul;46:199-205 PMID: 13759245
The use of the antiglobulin test in the diagnosis of bovine brucellosis.
Res Vet Sci. 1973 Mar;14(2):239-44 PMID: 4217918
Antigens on mouse and rat lymphocytes recognized by rabbit antiserum against rat brain: the quantitative analysis of a xenogeneic antiserum.
Eur J Immunol. 1975 Apr;5(4):274-81 PMID: 61868
Development of sheep thymus in relation to in utero thymectomy experiments.
Eur J Immunol. 1976 Oct;6(10):693-8 PMID: 1087847
Antibodies to major histocompatibility antigens produced by hybrid cell lines.
Nature. 1977 Apr 7;266(5602):550-2 PMID: 558524
Quantitative serological analysis of a rabbit anti-rat lymphocyte serum and preliminary biochemical characterisation of the major antigen recognised.
Transplantation. 1977 Apr;23(4):349-59 PMID: 68560
Purification with monoclonal antibody of a predominant leukocyte-common antigen and glycoprotein from rat thymocytes.
Eur J Immunol. 1979 Feb;9(2):155-9 PMID: 374095
Methods for binding cells to plastic: application to a solid-phase radioimmunoassay for cell-surface antigens.
J Immunol Methods. 1979;26(1):87-95 PMID: 438515
Structural studies of murine lymphocyte surface IgD.
J Immunol. 1980 May;124(5):2082-8 PMID: 6767780
Monoclonal antibody to a human leukocyte-specific membrane glycoprotein probably homologous to the leukocyte-common (L-C) antigen of the rat.
Eur J Immunol. 1980 Oct;10(10):737-44 PMID: 7428806
B220: a B cell-specific member of th T200 glycoprotein family.
Nature. 1981 Feb 19;289(5799):681-3 PMID: 6970340
The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues.
Immunology. 1981 Apr;42(4):593-600 PMID: 7016746
Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule.
J Exp Med. 1981 Apr 1;153(4):753-65 PMID: 6166706
Expression of Ly-5 on yolk sac and fetal liver cells of the mouse.
Immunogenetics. 1980;11(3):303-7 PMID: 7287081
High molecular weight lymphocyte surface proteins are structurally related and are expressed on different cell populations at different times during lymphocyte maturation and differentiation.
J Immunol. 1982 Apr;128(4):1676-84 PMID: 6460808
Detection of Thy-1, T-200, Lyt-1 and Lyt-2-bearing cells in the developing lymphoid organs of the mouse embryo in vivo and in vitro.
Eur J Immunol. 1982 Apr;12(4):262-71 PMID: 6124425
Lymphocyte cell surface glycoproteins which bind to soybean and peanut lectins.
Immunology. 1982 Aug;46(4):713-26 PMID: 6980823
Preferential but nonexclusive expression of macromolecular antigens on B-lineage cells.
Immunol Rev. 1982;69:141-59 PMID: 6983999
Fixation of Thy-1 in nervous tissue for immunohistochemistry: a quantitative assessment of the effect of different fixation conditions upon retention of antigenicity and the cross-linking of Thy-1.
J Histochem Cytochem. 1983 Feb;31(2):263-74 PMID: 6131917
On the function of Ly-5 in the regulation of antigen-driven B cell differentiation. Comparison and contrast with Lyb-2.
J Exp Med. 1983 Apr 1;157(4):1077-88 PMID: 6220106
Different forms of Ly-5 within the T-cell lineage.
Immunogenetics. 1983;17(6):649-54 PMID: 6602762
Four distinct antigen systems on human thymus and T cells defined by monoclonal antibodies: immunohistological and immunochemical studies.
Clin Exp Immunol. 1983 Jul;53(1):31-40 PMID: 6347477
MRC OX-22, a monoclonal antibody that labels a new subset of T lymphocytes and reacts with the high molecular weight form of the leukocyte-common antigen.
J Exp Med. 1983 Sep 1;158(3):795-810 PMID: 6224884
Modulation of in vitro immune responses by monoclonal antibody to T200 antigen.
Cell Immunol. 1983 Oct 1;81(1):71-80 PMID: 6225528
The lymphoid apparatus of the sheep: its growth, development and significance in immunologic reactions.
Adv Vet Sci Comp Med. 1973;17:225-63 PMID: 4593801

Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1985-06-00

Pages

347-53

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1453607

Subset

External Links

PubMed source PMC Full Text View journal details

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