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PMID: 3146642 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The effects of guanine and cytosine variation on dinucleotide frequency and amino acid composition in the human genome.

Journal of molecular evolution ·Vol. 27 ·No. 4 ·1988-00-00 ·Pages 321-5

Hanai R, Wada A

Abstract

One hundred twelve human DNA sequences were analyzed with respect to dinucleotide frequency and amino acid composition. The variation in guanine and cytosine (G + C) content revealed: (1) at 2-3 and 3-1 doublet positions CG discrimination is attenuated at high G + C, but TA disfavor is enhanced, and (2) several amino acids are subject to G + C change. These findings have been reported in part for collections of sequences from various species. The present study confirms that in a single organism--the human--the G + C effects do exist. Aspects of the argument that connects G + C with protein thermal stability are also discussed.

MeSH Terms
Animals Codon Cytosine Genes Genetic Variation Guanine Hominidae/genetics Humans Models, Genetic Models, Statistical
Chemicals
Codon Guanine Cytosine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hanai R
Department of Physics, Faculty of Science, University of Tokyo, Japan.
Wada A
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34 references, click to expand
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Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF02101194
Published
1988-00-00
Pages
321-5
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02101194 View journal details
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