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PMID: 3137580 Published · ppublish English Journal Article

Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 18 ·1988-09-00 ·Pages 6934-8

Uyttenhove C, Simpson RJ, Van Snick J

Abstract

Antigen-independent cell lines were derived from mouse helper T-cell clones by culture in autologous supernatant obtained after stimulation with concanavalin A. A factor, termed P40, supporting the growth of these lines was purified and characterized as a basic 32- to 39-kDa single-chain glycoprotein functionally distinct from previously identified T-cell growth factors and apparently unrelated structurally to any known protein. Of a number of cell lines, only helper T cells responded to P40, and this response was not mediated by either interleukin 2 or interleukin 4.

MeSH Terms
Amino Acid Sequence Animals Glycoproteins/analysis Interleukin-2/pharmacology Interleukin-4 Interleukin-9 Interleukins/analysis,pharmacology Mice Mice, Inbred C57BL Molecular Weight T-Lymphocytes/drug effects
Chemicals
Glycoproteins Interleukin-2 Interleukin-9 Interleukins Interleukin-4
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Uyttenhove C
Ludwig Institute for Cancer Research, Brussels Branch, Belgium.
Simpson R J
Van Snick J
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27 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.18.6934
Published
1988-09-00
Pages
6934-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC282093
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.85.18.6934 PMC Full Text View journal details
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