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PMID: 313056 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 5 ·1979-05-00 ·Pages 2430-3

Carson DA, Kaye J, Matsumoto S, Seegmiller JE, Thompson L

Abstract

Human malignant T cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity. When incubated with deoxyadenosine or thymidine, the malignant T cell lines rapidly accumulate toxic concentrations of dATP and dTTP, respectively. This unusual pattern of deoxyribonucleotide metabolism renders the malignant T cells especially vulnerable to the toxic effects of deoxyribonucleosides and related analogues.

MeSH Terms

B-Lymphocytes/metabolism Cell Line Deoxyadenine Nucleotides/metabolism Deoxyadenosines/metabolism Deoxyribonucleosides/toxicity Deoxyribonucleotides/metabolism Humans Nucleotidases/metabolism T-Lymphocytes/drug effects,metabolism

Chemicals

Deoxyadenine Nucleotides Deoxyadenosines Deoxyribonucleosides Deoxyribonucleotides Nucleotidases

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Carson D A

Kaye J

Matsumoto S

Seegmiller J E

Thompson L

References (27)

27 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.76.5.2430

Published

1979-05-00

Pages

2430-3

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC383615

Subset

External Links

PubMed source DOI: 10.1073/pnas.76.5.2430 PMC Full Text View journal details

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Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines.

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