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PMID: 3123396 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Levels of Listeria monocytogenes hemolysin are not directly proportional to virulence in experimental infections of mice.

Infection and immunity ·Vol. 56 ·No. 2 ·1988-02-00 ·Pages 534-6

Kathariou S, Rocourt J, Hof H, Goebel W

Abstract

The sulfhydryl-activated hemolysin of Listeria monocytogenes has been implicated in the virulence of the bacteria. Although loss of hemolytic activity by means of transposon mutagenesis is accompanied by loss of virulence in the mouse infection model, a direct relationship between in vitro production of hemolysin and virulence was not observed. Noticeable deviations in the extent of hemolysin production appeared to leave virulence unaffected.

MeSH Terms
Animals Gene Expression Regulation Hemolysin Proteins/physiology Listeria monocytogenes/pathogenicity Mice Molecular Weight
Chemicals
Hemolysin Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kathariou S
Institut für Genetik und Mikrobiologie, University of Würzburg, Federal Republic of Germany.
Rocourt J
Hof H
Goebel W
References (12)
12 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.56.2.534-536.1988
Published
1988-02-00
Pages
534-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC259317
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1128/iai.56.2.534-536.1988 PMC Full Text View journal details
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