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PMID: 3119721 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

How immunoglobulin V kappa genes rearrange.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 139 ·No. 11 ·1987-12-01 ·Pages 3834-9

Shapiro MA, Weigert M

Abstract

Recombination at the immunoglobulin kappa light chain locus creates a complete variable region gene and its reciprocal product. The results presented here show that reciprocal products may be substrates for secondary recombination and that at least one V kappa group rearranges by inversion.

MeSH Terms

Amino Acid Sequence Animals Antibody Diversity Base Sequence Genes, Immunoglobulin Immunoglobulin J-Chains/genetics Immunoglobulin Switch Region/genetics Immunoglobulin Variable Region/genetics Immunoglobulin kappa-Chains/genetics Mice Models, Genetic Molecular Sequence Data Plasmacytoma/pathology Recombination, Genetic Tumor Cells, Cultured

Chemicals

Immunoglobulin J-Chains Immunoglobulin Variable Region Immunoglobulin kappa-Chains

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Shapiro M A

Fox Chase Cancer Center, Philadelphia, PA 19111.

Weigert M

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1987-12-01

Pages

3834-9

Language

English

Region

United States

NLM ID

2985117R

Subset

Grants

NIGMS NIH HHS · GM-20964-14 · United States

Databases

GENBANK

M18406, M18407, M18408, M18409

External Links

PubMed source View journal details

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How immunoglobulin V kappa genes rearrange.

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