Ionising radiation has no influence on scrapie incubation period in mice.

Veterinary microbiology ·Vol. 13 ·No. 3 ·1987-03-00 ·Pages 211-23

Fraser H, Farquhar CF

Abstract

Scrapie has an early non-clinical stage when replication of agent occurs in lymphoreticular organs. Whole-body irradiation failed to alter the incubation or neuropathology of the disease. Many experiments were carried out with different strains of scrapie agent and host, doses and timing of irradiation. The results suggest that mitotically quiescent cells are involved in agent replication.

MeSH Terms

Animals Brain/pathology Cell Division Chimera Disease Models, Animal Gamma Rays Mice Mice, Inbred C3H Mice, Inbred C57BL Prions/physiology,radiation effects Scrapie/genetics,microbiology,pathology Sheep Virus Replication/radiation effects Whole-Body Irradiation

Chemicals

Prions

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Fraser H

AFRC & MRC Neuropathogenesis Unit, Edinburgh, Gt. Britain.

Farquhar C F

Article Info

Journal

Veterinary microbiology

Abbr.

Vet Microbiol

ISSN

0378-1135

DOI

10.1016/0378-1135(87)90084-8

Published

1987-03-00

Pages

211-23

Language

English

Region

Netherlands

NLM ID

7705469

Subset

External Links

PubMed source DOI: 10.1016/0378-1135(87)90084-8 View journal details

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Ionising radiation has no influence on scrapie incubation period in mice.

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