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PMID: 3114151 Published · ppublish English Journal Article

Gamma interferon-mediated increase in the number of Ia-bearing macrophages during infection with Listeria monocytogenes.

Infection and immunity ·Vol. 55 ·No. 9 ·1987-09-00 ·Pages 2300-3

Koga T, Mitsuyama M, Handa T, Watanabe Y, Nomoto K

Abstract

The role of gamma interferon (IFN-gamma) in an increase in Ia-bearing macrophages during Listeria monocytogenes infection was studied. The peritoneal macrophages from L. monocytogenes-infected mice contained a high proportion of Ia. Intraperitoneal injection of the supernatant from a culture of spleen cells from L. monocytogenes-infected mice induced Ia-rich exudates in normal mice. The Ia-inducing activity in the culture supernatant was abrogated by the pretreatment of spleen cells with anti-Thy-1.2 antibody plus complement. Immunoadsorption of the culture supernatant with anti-recombinant IFN-gamma antibody and protein A-Sepharose CL-4B completely abrogated its Ia-inducing activity. These results suggested that an increase in Ia-bearing macrophages during L. monocytogenes infection was attributable to T-cell-derived IFN-gamma.

MeSH Terms
Animals Histocompatibility Antigens Class II/immunology Interferon-gamma/physiology Listeriosis/immunology Lymphokines/physiology Macrophage Activation Macrophage-Activating Factors Macrophages/immunology Mice T-Lymphocytes/immunology Time Factors
Chemicals
Histocompatibility Antigens Class II Lymphokines Macrophage-Activating Factors Interferon-gamma
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Koga T
Mitsuyama M
Handa T
Watanabe Y
Nomoto K
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31 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.55.9.2300-2303.1987
Published
1987-09-00
Pages
2300-3
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC260696
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.55.9.2300-2303.1987 PMC Full Text View journal details
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