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PMID: 3111858 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Lysis of nonnucleated red blood cells by cytotoxic T lymphocytes.

European journal of immunology ·Vol. 17 ·No. 7 ·1987-07-00 ·Pages 1073-4

Lanzavecchia A, Staerz UD

Abstract

To establish the role of direct membrane damage in cytotoxic T lymphocytes (CTL)-mediated lysis we investigated whether CTL would be capable of lysing nonnucleated target cells. By antibody-mediated targeting we show that CTL are indeed capable of lysing sheep and human red blood cells.

MeSH Terms

Animals Antibodies, Monoclonal/administration & dosage,immunology Antibody Specificity Antibody-Dependent Cell Cytotoxicity Antigens, Differentiation, T-Lymphocyte Antigens, Surface/analysis,immunology Clone Cells Erythrocytes/immunology Humans Mice Sheep/blood T-Lymphocytes, Cytotoxic/immunology

Chemicals

Antibodies, Monoclonal Antigens, Differentiation, T-Lymphocyte Antigens, Surface

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lanzavecchia A

Staerz U D

Article Info

Journal

European journal of immunology

Abbr.

Eur J Immunol

ISSN

0014-2980

DOI

10.1002/eji.1830170727

Published

1987-07-00

Pages

1073-4

Language

English

Region

Germany

NLM ID

1273201

Subset

External Links

PubMed source DOI: 10.1002/eji.1830170727 View journal details

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Lysis of nonnucleated red blood cells by cytotoxic T lymphocytes.

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