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PMID: 3107982 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Molecular analysis of the locus elav in Drosophila melanogaster: a gene whose embryonic expression is neural specific.

The EMBO journal ·Vol. 6 ·No. 2 ·1987-02-00 ·Pages 425-31

Campos AR, Rosen DR, Robinow SN, White K

Abstract

The embryonic lethal abnormal visual system (elav) locus in Drosophila melanogaster, a vital gene mapping within the 1B5-1B9 region of the X-chromosome has been cloned and analysed. Previous developmental analyses have shown that in addition to the embryonic requirement there is a post-embryonic requirement for elav function in the cells of the visual system. A DNA segment containing elav+ function was defined through germ line transformation experiments. This region encodes three embryonic poly(A)+ RNAs and two adult transcripts which are preferentially expressed in the head. In situ hybridization experiments clearly demonstrate that the embryonic expression of elav is restricted to the nervous system.

MeSH Terms
Animals Cloning, Molecular DNA/metabolism Drosophila melanogaster/embryology,genetics Embryo, Nonmammalian Genes Nucleic Acid Hybridization Plasmids Transcription, Genetic X Chromosome
Chemicals
DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Campos A R
Rosen D R
Robinow S N
White K
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42 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1987-02-00
Pages
425-31
Language
English
Region
England
NLM ID
8208664
PMCID
PMC553413
Subset
IM
Grants
NIGMS NIH HHS · GM 07122 · United States
NIGMS NIH HHS · GM-33205 · United States
External Links
PubMed source PMC Full Text View journal details
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