Pertussis in a rural area of Kenya: epidemiology and a preliminary report on a vaccine trial.

Bulletin of the World Health Organization ·Vol. 56 ·No. 5 ·1978-00-00 ·Pages 773-80

Mahieu JM, Muller AS, Voorhoeve AM, Dikken H

Abstract

暂无摘要

Keywords

Africa Africa South Of The Sahara Age Distribution Age Factors Antibodies Antibody Formation--analysis Biology Data Analysis Data Collection Delivery Of Health Care Demographic Factors Developing Countries Diseases--prevention and control Eastern Africa English Speaking Africa Evaluation Examinations And Diagnoses Health Health Services Immunity Immunization Immunologic Factors Incidence Kenya Laboratory Examinations And Diagnoses Laboratory Procedures Measurement Medicine Mortality Physiology Population Population Characteristics Population Dynamics Preventive Medicine Primary Health Care Research Methodology Rural Population Vaccination

MeSH Terms

Adolescent Child Child, Preschool Diphtheria Toxoid/therapeutic use Female Humans Immunization Schedule Infant Infant, Newborn Kenya Male Pertussis Vaccine/therapeutic use Pilot Projects Rural Health Tetanus Toxoid/therapeutic use Whooping Cough/epidemiology,prevention & control

Chemicals

Diphtheria Toxoid Pertussis Vaccine Tetanus Toxoid

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Mahieu J M

Muller A S

Voorhoeve A M

Dikken H

Other Abstracts

eng

In the course of 2 years of surveillance of whooping cough by fortnightly home visits among a population of 24,000 in a rural area of Kenya, 918 cases were observed with a peak of 218 in December 1974-January 1975. The attack rate was highest (15.8%) during the 1st year of life

for those ages 0-6 it was 12.8%. 90% of the cases occurred in children age 6 or younger. The median age was 3.5 years, the age range 1 month-13 years. Girls were significantly more affected than boys. The overall case fatality rate was 1.3% but among infants, it was 2.5 times higher. In order to contribute to the improvement of immunization coverage in countries where health resources are limited, a schedule of child immunization requiring a minimum number of contacts with the children was introduced into the study area with the aim of evaluating its effectiveness in protecting children from clinical pertussis. In this trial, the effect of 2 and 3 diphtheria-pertussis-tetanus (DPT) vaccine doses was compared. Pertussis agglutinating antibody determinations showed an equally satisfactory response after 2 and 3 DPT vaccine doses. (author's)

References (9)

9 references, click to expand

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Am J Med Sci. 1951 Sep;222(3):333-61 PMID: 14877820
Poliomyelitis: epidemiology and prophylaxis. 4. Serological and virological surveys conducted after a mass vaccination campaign for the control of a threatening poliomyelitis epidemic.
Bull World Health Organ. 1977;55(6):747-53 PMID: 202417
Machakos project studies. Agents affecting health of mother and child in a rural area of Kenya. IV: The epidemiology of pertussis.
Trop Geogr Med. 1978 Mar;30(1):125-39 PMID: 675822
Machakos project studies. Agents affecting health of mother and child in a rural area of Kenya. I. Introduction: study design and methodology.
Trop Geogr Med. 1977 Sep;29(3):291-302 PMID: 595135
Poliomyelitis in the Netherlands 1958-69: the influence of a vaccination programme with inactivated poliovaccine.
Bull World Health Organ. 1972;46(6):735-45 PMID: 4538535
Whooping-cough vaccination. An assessment.
Lancet. 1974 Aug 31;2(7879):511-3 PMID: 4137358
Epidemiological evaluation of immunisation and other factors in the control of whooping-cough.
Lancet. 1976 Feb 28;1(7957):471-4 PMID: 55731
Protection by pertussis vaccine. Little cause for concern.
Lancet. 1976 May 15;1(7968):1065-7 PMID: 57464
Simultaneous administration of smallpox, measles, yellow fever, and diphtheria-pertussis-tetanus antigens to Nigerian children.
Bull World Health Organ. 1973;48(2):175-81 PMID: 4541683

Article Info

Journal

Bulletin of the World Health Organization

Abbr.

Bull World Health Organ

ISSN

0042-9686

Published

1978-00-00

Pages

773-80

Language

English

Region

Switzerland

NLM ID

7507052

PMCID

PMC2395676

Subset

External Links

PubMed source PMC Full Text View journal details

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Pertussis in a rural area of Kenya: epidemiology and a preliminary report on a vaccine trial.

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