Pseudomonas exotoxin coupled to a monoclonal antibody against ovarian cancer inhibits the growth of human ovarian cancer cells in a mouse model.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 84 ·No. 8 ·1987-04-00 ·Pages 2474-8

Willingham MC, FitzGerald DJ, Pastan I

Abstract

In an effort to devise an alternative treatment for human ovarian cancer, we have isolated a monoclonal antibody (OVB-3) that reacts with all ovarian cancers tested (10/10) but few normal tissues. An immunotoxin produced by coupling OVB-3 to Pseudomonas exotoxin kills ovarian cancer cells in tissue culture and prolongs the life of animals bearing human ovarian cancers. These data suggest that this immunotoxin should be evaluated as a treatment for ovarian cancer in women.

MeSH Terms

ADP Ribose Transferases Animals Antibodies, Monoclonal/therapeutic use Bacterial Toxins Cell Line Exotoxins/therapeutic use Female Humans Immunotherapy Liver/pathology Mice Neoplasm Transplantation Ovarian Neoplasms/pathology,therapy Pseudomonas aeruginosa Transplantation, Heterologous Virulence Factors

Chemicals

Antibodies, Monoclonal Bacterial Toxins Exotoxins Virulence Factors ADP Ribose Transferases toxA protein, Pseudomonas aeruginosa

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Willingham M C

FitzGerald D J

Pastan I

References (10)

10 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.84.8.2474

Published

1987-04-00

Pages

2474-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC304674

Subset

External Links

PubMed source DOI: 10.1073/pnas.84.8.2474 PMC Full Text View journal details

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Pseudomonas exotoxin coupled to a monoclonal antibody against ovarian cancer inhibits the growth of human ovarian cancer cells in a mouse model.

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