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PMID: 3099640 Published · ppublish English Journal Article

High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant.

Antimicrobial agents and chemotherapy ·Vol. 30 ·No. 5 ·1986-11-00 ·Pages 664-70

Morse SA, Johnson SR, Biddle JW, Roberts MC

Abstract

Recently, strains of Neisseria gonorrhoeae have been isolated which are highly resistant to tetracycline (MICs of 16 to 64 micrograms/ml). This resistance was due to the acquisition of the resistance determinant tetM, a transposon-borne determinant initially found in the genus Streptococcus and more recently in Mycoplasma hominis, Ureaplasma urealyticum, and Gardnerella vaginalis. In N. gonorrhoeae, the tetM determinant was located on a 25.2-megadalton plasmid. This plasmid arose from the insertion of tetM into the 24.5-megadalton gonococcal conjugative plasmid. The tetM determinant could be transferred to suitable recipient strains of N. gonorrhoeae by both genetic transformation and conjugation.

MeSH Terms
Conjugation, Genetic Drug Resistance, Microbial Neisseria gonorrhoeae/drug effects,genetics R Factors Streptococcus/genetics Tetracycline/pharmacology Transformation, Bacterial
Chemicals
Tetracycline
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Morse S A
Johnson S R
Biddle J W
Roberts M C
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35 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.30.5.664
Published
1986-11-00
Pages
664-70
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC176510
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.30.5.664 PMC Full Text View journal details
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