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PMID: 3097240 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.

The Journal of experimental medicine ·Vol. 164 ·No. 6 ·1986-12-01 ·Pages 2113-8

Collart MA, Belin D, Vassalli JD, de Kossodo S, Vassalli P

Abstract

Exposure of mouse resident and thioglycollate-elicited peritoneal macrophages to IFN-gamma leads to a marked increase in the TNF-alpha (tumor necrosis factor/cachectin), IL-1 and u-PA (urokinase-type plasminogen activator) mRNA levels. Nuclear run-on experiments show that IFN-gamma acts by enhancing the transcription of these three genes. Transcription of these three genes is also rapidly and transiently induced by cycloheximide, an inhibitor of protein synthesis, indicating that they are under the control of short-lived repressors.

MeSH Terms
Animals Cycloheximide/pharmacology Glycoproteins/biosynthesis,genetics Interferon-gamma/pharmacology Interleukin-1/biosynthesis,genetics Macrophages/drug effects,metabolism Mice Mice, Inbred C3H Mice, Inbred CBA Repressor Proteins/metabolism Time Factors Transcription Factors/metabolism Transcription, Genetic/drug effects Tumor Necrosis Factor-alpha Urokinase-Type Plasminogen Activator/biosynthesis,genetics
Chemicals
Glycoproteins Interleukin-1 Repressor Proteins Transcription Factors Tumor Necrosis Factor-alpha Interferon-gamma Cycloheximide Urokinase-Type Plasminogen Activator
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Collart M A
Belin D
Vassalli J D
de Kossodo S
Vassalli P
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20 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.164.6.2113
Published
1986-12-01
Pages
2113-8
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2188497
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.164.6.2113 PMC Full Text View journal details
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