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PMID: 3097061 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Abnormality of Leu 2+7+ cells in acquired immune deficiency syndrome (AIDS), AIDS-related complex, and asymptomatic homosexuals.

Journal of clinical immunology ·Vol. 6 ·No. 6 ·1986-11-00 ·Pages 502-9

Gupta S

Abstract

Peripheral blood mononuclear cells from patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), asymptomatic homosexuals, and healthy heterosexuals were analyzed for the proportions and numbers of Leu 7+ cells and double-labeled Leu 2+7+ cells and for the natural killer functions. A significant increase in the proportions and numbers of Leu 7+ cells was observed in patients with AIDS and ARC and in asymptomatic homosexuals compared to healthy heterosexual men. The proportions of Leu 2+7+ cells were significantly increased in AIDS, ARC, and asymptomatic homosexuals, whereas the numbers were increased in asymptomatic homosexuals and ARC but not in AIDS compared to heterosexual controls. A significant increase in the number of Leu 2+7+ cells was observed in AIDS with Kaposi's sarcoma but not in AIDS with opportunistic infections. The natural killer function was significantly depressed in patients with AIDS and ARC and in asymptomatic homosexuals. These data suggest that the quantitative abnormalities of Leu 2+7+ cells appear early during the evolution of immunologic changes in HTLV III/LAV infection.

MeSH Terms
AIDS-Related Complex/immunology Acquired Immunodeficiency Syndrome/immunology Adult Antigens, Differentiation, T-Lymphocyte Antigens, Surface Homosexuality Humans Killer Cells, Natural/immunology Lymphocytes/immunology Male
Chemicals
Antigens, Differentiation, T-Lymphocyte Antigens, Surface
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gupta S
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25 references, click to expand
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/BF00915256
Published
1986-11-00
Pages
502-9
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
Grants
NIAID NIH HHS · AI-20717 · United States
External Links
PubMed source DOI: 10.1007/BF00915256 View journal details
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