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PMID: 3094964 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

One heavy chain variable region gene segment subfamily in the BALB/c mouse contains 500-1000 or more members.

Cell ·Vol. 47 ·No. 3 ·1986-11-07 ·Pages 461-70

Livant D, Blatt C, Hood L

Abstract

Nucleic acid hybridization studies suggest that 500-1000 or more heavy chain variable (VH) gene segments related to one VH gene segment (J558) are present in the genome of the BALB/c mouse. The implications of this result regarding the overall size, sequence organization, and evolution of the mouse family of VH gene segments are discussed.

MeSH Terms
Animals Genetic Markers Immunoglobulin Heavy Chains/genetics Immunoglobulin Variable Region/genetics Mathematics Mice Mice, Inbred BALB C/genetics Nucleic Acid Hybridization Recombination, Genetic Temperature
Chemicals
Genetic Markers Immunoglobulin Heavy Chains Immunoglobulin Variable Region
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Livant D
Blatt C
Hood L
Article Info
Journal
Cell
Abbr.
Cell
ISSN
0092-8674
DOI
10.1016/0092-8674(86)90603-3
Published
1986-11-07
Pages
461-70
Language
English
Region
United States
NLM ID
0413066
Subset
IM
Grants
NIAID NIH HHS · AI10781 · United States
NIGMS NIH HHS · GM07616 · United States
External Links
PubMed source DOI: 10.1016/0092-8674(86)90603-3 View journal details
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